نتایج جستجو برای: myelin protection
تعداد نتایج: 193720 فیلتر نتایج به سال:
Multiple sclerosis is an autoimmune CNS-disease characterized by inflammatory neurodegenerative events occurring with de- and remyelination. Recent evidence show that demyelinated neurons are less excitable than myelinated ones while at early stages of remyelination these neurons seem to be hyperexcitable. The latter is a transitory condition that, very likely, leads to impaired neuronal networ...
We have previously shown that increased nonenzymatic glycosylation occurs in peripheral nervous tissue of diabetic humans and animals, primarily on the PO-protein of peripheral nerve myelin. The pathophysiologic mechanism by which this biochemical alteration leads to myelin breakdown and removal is not as yet understood. In the present study we show that advanced glycosylation end-product (AGE)...
1. A myelin-like membrane fraction was isolated from developing rat brain by a new method. 2. The chemical composition and morphology of the fraction are described. 3. The myelin-like fraction is similar to myelin in characteristic enzyme activity but differs in the absence of basic protein and cerebrosides. No similarity to other subcellular fractions was observed. 4. It is suggested that the ...
Niemann-Pick Diseases (NPD) is lysosomal storage diseases caused by Acid Sphingo Myelinase (ASM) deficiency, which catalyzes the hydrolysis of Myelin
Leukodystrophies are a group of hereditary progressive diseases the central nervous system characterized by selective lesions in white matter with specific involvement glial cells. There hypomyelinating (absence myelin deposition), demyelinating (loss previously deposited myelin), dysmyelinating (deposition structurally or biochemically abnormal and myelinolytic leukodystrophies (myelin vacuoli...
The unlabeled peroxidase-antiperoxidase method has been used with antiserum against "myelin-associated glycoprotein" to establish the presence of the glycoprotein in myelin and myelin-forming cells of the developing rat nervous system. Myelin-associated glycoprotein is found in oligodendroglial cytoplasm before the beginning of myelination. Staining intensity of oligodendroglia increases during...
Inflammatory response following central nervous system (CNS) injury contributes to progressive neuropathology and reduction in functional recovery. Axons are sensitive to mechanical injury and toxic inflammatory mediators, which may lead to demyelination. Although it is well documented that degenerated myelin triggers undesirable inflammatory responses in autoimmune diseases such as multiple sc...
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