the subject of transplant immunosuppression has generated significant interest in recent years. excellent immunosuppression, advances in surgical technique, post-transplantation care, and infection control have resulted in excellent outcomes. there is widespread support for the notion that the fundamental objective in transplant immunology should be the achievement of specific graft tolerance. ...

there are wide individual differences in pharmacokinetic parameters of mycophenolate mofetil (mmf) among transplanted patients. some studies have shown that single nucleotide polymorphisms (snps) of the uridine diphosphate glucuronosyl transferase1a9 (ugt1a9) are responsible for these differences in early days after transplantation. therefore it was decided to evaluate the influence of ugt poly...

Acquired pure red-cell aplasia is a rare disorder that can be either idiopathic or associated with certain autoimmune diseases, pregnancy, lymphoproliferative disorders, nutritional deficiencies, or medicines. We present a deceased-donor renal transplant patient who developed pure red-cell aplasia associated with mycophenolate mofetil or tacrolimus and was treated with cyclosporine. A 20-year-o...

The main treatment for pemphigus vulgaris are systemic corticosteroids and immunosuppressive agents, but due to adverse reactions and therapeutic failure, new drugs such as rituximab and mycophenolate mofetil have been used. In this case report are described two cases of severe pemphigus vulgaris refractory to various treatments, with resolution after use of rituximab and mycophenolate mofetil,...

Several new medications are now available for immunosuppression in the kidney transplant field. Tacrolimus and mycophenolate mofetil were first introduced for immunosuppression in renal transplantation in the mid 1990s. Since then, the combination of tacrolimus and mycophenolate mofetil has been evaluated in numerous clinical trials. The outcomes of these trials have varied due to differences i...

BACKGROUND/AIM Mycophenolate mofetil could be a useful antiproliferative drug in glaucoma filtering surgery. In this study the authors set out to investigate whether growth inhibition of mycophenolate mofetil on human Tenon fibroblasts is mediated by guanosine depletion. METHODS Cultured human Tenon fibroblasts were incubated in various concentrations of mycophenolate mofetil with and without...

Aplastic anemia is a relatively uncommon disease and conventional management options include immunosuppressive drugs and/or haematopoeitic stem cell transplantation. It is now known that the pathogenesis of aplastic anemia is immune mediated. Mycophenolate mofetil is a common immunosuppressive drug now used mainly in prophylaxis of graft rejection in organ transplant and also for prevention/tre...