نتایج جستجو برای: mutacin

تعداد نتایج: 77  

2018
Johan A. Kers Robert E. Sharp Anthony W. Defusco Jae H. Park Jin Xu Mark E. Pulse William J. Weiss Martin Handfield

Lantibiotics offer an untapped pipeline for the development of novel antibiotics to treat serious Gram-positive (+) infections including Clostridium difficile. Mutacin 1140 (MU1140) is a lantibiotic produced by Streptococcus mutans and acts via a novel mechanism of action, which may limit the development of resistance. This study sought to identify a lead compound for the treatment of C. diffic...

2013
Miula Portelinha Braga Augusta Piovesan Natália Valarini Sandra Mara Maciel Flaviana Bombarda de Andrade Regina Célia Poli-Frederico

The objective of this study was to analyze the genotypic diversity, frequency of serotypes and the detection of mutacins from Streptococcus mutans isolates in caries-free and caries-active individuals. A total of 260 S. mutans isolated from 28 individuals with and without dental caries were subjected to AP-PCR and PCR screening of glucosyltransferase B, mutacin and serotype genes, which showed ...

Journal: :Physical chemistry chemical physics : PCCP 2014
Shada A Alsharif Liao Y Chen Alfredo Tlahuice-Flores Robert L Whetten Miguel Jose Yacaman

The interactions between functionalized noble-metal particles in an aqueous solution are central to applications relying on controlled equilibrium association. Herein, we obtain the potentials of mean force (PMF) for pair-interactions between functionalized gold nanoparticles (AuNPs) in physiological saline. These results are based upon >1000 ns experiments in silico of all-atom model systems u...

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