BACKGROUND AND OBJECTIVES Simvastatin's properties are suggestive of a potential pathophysiologic role in pulmonary hypertension. The objectives of this study were to investigate changes of pulmonary pathology and gene expressions, including endothelin (ET)-1, endothelin receptor A (ERA), inducible nitric oxide synthase (NOS2), endothelial nitric oxide synthase (NOS3), matrix metalloproteinase ...

To examine the effects of aliskiren, a small-molecule renin inhibitor, on cancer cachexia and to explore the underlying mechanisms. A cancer cachexia model was established by subcutaneously injecting C26 mouse colon carcinoma cells into isogenic BALB/c mice. Aliskiren was administered intragastrically [10 mg/kg body weight (BW)] on day 5 (as a preventive strategy, AP group) or on day 12 (as a t...

the purpose of this quasi-experimental study was to examine the effect of the Z-track intramuscular injection technique on severity of pain,bruises and drug leakage at the injection site.the subjects of the study were 60 adult medical-surgical patients at Kerman university of medical sciences hospitals.subjects served as their own controls by receiving both z-track and standard  intramuscular i...

Botulinum toxin, the causal agent of botulism, is employed in therapeutic settings for a number purposes. toxin injections address aesthetic issues induced or worsened by muscle contraction controlling local neurotransmission. Therapy has transient impact; recovery generally clinically visible few months following treatment. Improper injection placement diffusion to unintended locations might r...

The drainage pattern and the structure of the pulmonary veins have been described quantitatively in a series of fetal and child lungs after injection of the veins with a radio-opaque medium. The drainage pattern of the pre-acinar region is complete by half-way through gestation and corresponds with the growth of the pulmonary arteries. There is new growth of veins within the acinus during child...

objective(s): pregabalin (pgb) is a new antiepileptic drug that has received fda approval for patient who suffers from central neuropathic pain, partial seizures, generalized anxiety disorder, fibromyalgia and sleep disorders. this study was undertaken to evaluate the possible adverse effects of pgb on the muscular system of mice. materials and methods: to evaluate the effect of pgb on skeletal...