objective in previous studies, the relaxant, anticholinergic (functional antagonism), antihistaminic and its stimulatory effects on b-adrenoceptors of nigella sativa have been demonstrated on guinea pig tracheal chains. in the present study, the relaxant effects of hydro-ethanolic, macerated aqueous (ma) and lipid-free macerated aqueous (lfma) extract of nigella sativa on tracheal chains of gui...

BACKGROUND Alkaloids extracted from lotus leaves (AELL) can relax vascular smooth muscle. However, whether AELL has a similar relaxant role on airway smooth muscle (ASM) remains unknown. This study aimed to explore the relaxant property of AELL on ASM and the underlying mechanism. METHODS Alkaloids were extracted from dried lotus leaves using the high temperature rotary evaporation extraction...

Corresponding author: Dr Arsen Uvelin, M.D. Clinical centre of Vojvodina, Emergency Centre, Department of Anaesthesia and Intensive Therapy Hajduk Veljka 1, 21000 Novi Sad, Serbia e-mail: [email protected] Sir, the “timing principle” utilises administration of a single bolus dose of nondepolarizing muscle relaxant (NMR), followed by an induction drug at the onset of muscular weakness (1) was...

The flexible laryngeal mask airway (FLMA) is becoming more and more popular in general anesthesia during surgery of head, neck and upper chest. But very limited information has been published about whether muscle relaxant was necessary or not for anesthesia with FLMA. To investigate whether low-dose muscle relaxant is necessary in preventing ventilation leak of FLMA in radical mastectomy, forty...

This article concerns the synthesis and biological activities of some N-(1-(3,4-dimethoxyphenyl)propan-2-yl) amides as isoquinoline precursors compounds with smooth muscle (SM) relaxant activity. Aim: find activity compare it papaverine, an alkaloid that has been known a brain coronary vasodilator SM relaxant. Materials methods: In silico simulation PASS online program predicts for compounds. T...

Isolated human bronchial muscle was stimulated to contract by carbachol, acetylcholine, and histamine. The effects of adrenaline and the alphaand beta-adrenergic blocking drugs on these contractions were then observed. Phentolamine and phenoxybenzamine potentiated the relaxant effect of adrenaline. Phenoxybenzamine alone caused relaxation of bronchial muscle and inhibited the response to the va...

In searching for the 'ideal' muscle relaxant for use with intravenous regional anaesthesia, muscle relaxation was assessed with and without the addition of Atracurium to Bier's Block in four volunteers. This was followed by a clinical study of 36 patients with wrist fractures to confirm the drug's safety and examine the possible clinical advantages of using a muscle relaxant. The addition of 2 ...

background: muscle relaxant agents usually use to facilitate tracheal intubation; however, sometimes limitations exist. magnesium (mg) sulfate is a candidate for muscle relaxant substitute. this study was designed to determine the effect of mg sulfate accompanied with propofol and fentanyl in patients undergoing ophthalmic surgery. materials and methods: in a double?blind randomized protocol an...