Previous reports suggest that burn-induced muscle proteolysis can be inhibited by treatment with GSK-3beta inhibitors, suggesting that burn injury may be associated with increased GSK-3beta activity. The influence of burn injury on muscle GSK-3beta activity, however, is not known. We determined the effect of a 30% total body surface full-thickness burn injury in rats on muscle GSK-3beta activit...

1. Stretch-induced muscle injury results in the damage that causes reduced force and increased membrane permeability. This muscle damage is caused, in part, by ionic entry through stretch-activated channels and blocking these channels with Gd3+ or streptomycin reduces the force deficit associated with damage. 2. Dystrophin-deficient muscles are more susceptible to stretch-induced muscle injury ...

Spinal Cord Injury (SCI) level tinggi dapat menyebabkan gangguan pada pernapasan yang mengancam nyawa pasien. One of the interventions that can be given to individuals with SCI in reducing complications respiratory problems is Respiratory Muscle Training (RMT). (RMT) a technique aims improve function muscles through specific exercises. This study determined effectiveness muscle training spinal ...

Animal models implicate multiple mechanical factors in the initiation of exercise-induced muscle injury. Muscle injury has been widely studied in humans, but few data exist regarding the underlying cause of muscle injury. This study sought to examine the role of torque per active muscle volume in muscle injury. Eight subjects performed 80 electrically stimulated [via electromyostimulation (EMS)...

plexus injury. Few studies report the rate of revision surgeries following free functional muscle transfers. We examinedthe reoperation rate and indication for reoperation after primary reconstruction of upper extremity function with a freegracilis transfer after brachial plexus injury.Methods: From 2003-2016, we identified 25 patients who underwent a free functional gracilis ...

Strength deficits associated with eccentric contraction-induced muscle injury stem, in part, from excitation-contraction uncoupling. FKBP12 is a 12-kDa binding protein known to bind to the skeletal muscle sarcoplasmic reticulum Ca2+ release channel [ryanodine receptor (RyR1)] and plays an important role in excitation-contraction coupling. To assess the effects of FKBP12 deficiency on muscle inj...

The current treatment options for soft tissue injuries remain suboptimal and often result in delayed/incomplete recovery of damaged muscle. The current study aimed to evaluate the effects of oral Prosopis glandulosa treatment on inflammation and regeneration in skeletal muscle after contusion injury, in comparison to a conventional treatment. The gastrocnemius muscle of rats was subjected to ma...

BACKGROUND Owing to the complexity and heterogeneity of muscle injuries, a generally accepted classification system is still lacking. AIMS To prospectively implement and validate a novel muscle injury classification and to evaluate its predictive value for return to professional football. METHODS The recently described Munich muscle injury classification was prospectively evaluated in 31 Eu...