cardiology (ESC). Eur Heart J 2011;32:2851–6. 75. Agabiti Rosei E, de Simone G, Mureddu GF, Trimarco B, Verdecchia P, Volpe M. for the Joint Committee of the Italian Society of Hypertension (SIIA), Italian Society of Cardiology (SIC), Associazione Nazionale Medici Cardiologi Ospedalieri (ANMCO). Arterial hypertension and cardiac damage: diagnostic and therapeutic guidelines. High Blood Press Ca...

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a by-product o f t he trichlorophenol (herbicide) production and is also produced through a variety of combustion processes. It appears that TCDD is a ubiquitous chemical, particularly in industrialised countries, and the liver is the target organ of its toxicity. The prominent hepatotoxic effect of TCDD is progressive centrilobular necrosis. Th...