BACKGROUND Treatment of Staphylococcus aureus colonization before surgery reduces risk of surgical site infection (SSI). The regimen of nasal mupirocin ointment and topical chlorhexidine gluconate is effective, but cost and patient compliance may be a barrier. Nasal povidone-iodine solution may provide an alternative to mupirocin. METHODS We conducted an investigator-initiated, open-label, ra...

Mupirocin has been used against Gram-positive pathogenic bacteria, and is a specific inhibitor of bacterial isoleucyl-tRNA synthetase. In this work, we have determined the prevalence of mupirocin resistance among staphylococci isolated from a Korean hospital, and have investigated the characteristics of the resistance. In Staphylococcus aureus, the prevalence of high-level mupirocin resistance ...

BACKGROUND Staphylococcus aureus nasal carriage is a major risk factor for nosocomial S. aureus infection. Studies show that intranasal mupirocin can prevent nosocomial surgical site infections. No data are available on the efficacy of mupirocin in nonsurgical patients. OBJECTIVE To assess the efficacy of mupirocin prophylaxis in preventing nosocomial S. aureus infections in nonsurgical patie...

OBJECTIVE To review the evidence evaluating perioperative intranasal mupirocin for the prevention of surgical-site infections according to type of surgical procedure. DESIGN Systematic review and meta-analysis of published clinical trials. SETTING Studies included were either randomized clinical trial or prospective trials at a single institution that measured outcomes both before and after...

Abstract Background Current antimicrobial susceptibility/resistance data versus skin and soft tissue infection (SSTI) pathogens help to guide empirical treatment using topical antimicrobials. Objectives To assess the in vitro activity resistance rates of fusidic acid, mupirocin, ozenoxacin comparator agents against isolated from patients with SSTIs Canada. Methods SSTI isolates MSSA (n = 422), ...

Mupirocin is the topical antimicrobial agent which is used for the treatment of methicillin resistant Staphylococcus aureus (MRSA). However the prevalence of mupirocin resistance in MRSA has increased with the extensive and widespread use of this agent in hospital settings. The present study was attempted to evaluate the low level and high level resistance to mupirocin in MRSA isolates by diffe...

BACKGROUND Erythrasma is a benign dermatosis that typically occurs on intertriginous skin. PURPOSE We describe a series of nine men with erythrasma that were successfully treated with mupirocin 2% ointment monotherapy. METHODS AND MATERIALS We reviewed PubMed for the following terms: erythrasma, mupirocin, ointment, treatment. We also reviewed papers containing these terms and their referen...

The investigation deals with the affection of permeation of mupirocin from the Bactroban® Leciva ointment through full-thickness pig ear skin by alaptide that was applied in micronized or nanonized form as a potential excipient. Alaptide, (S)-8-methyl-6,9-diazaspiro[4.5]decan-7,10-dione, was the original Czech compound. It was discovered that micronized alaptide significantly enhanced the perme...

Nasal carriage of Staphylococcus aureus is a risk factor for the development of infections caused by S. aureus in haemodialysis patients. This study compared the incidence of bacteraemia caused by S. aureus during 6 months of use of nasal 2% calcium mupirocin ('Nasal Bactroban') 3-times a week for nasal carriers with the incidence observed previously in the same dialysis unit without the use of...

Mupirocin is the topical antimicrobial agent which is used for the treatment of methicillin resistant Staphylococcus aureus (MRSA). However the prevalence of mupirocin resistance in MRSA has increased with the extensive and widespread use of this agent in hospital settings. The present study was attempted to evaluate the low level and high level resistance to mupirocin in MRSA isolates by diffe...