Melanotransferrin (MTf) or tumor antigen p97 is a transferrin homolog that binds one iron (Fe) atom and has been suggested to play roles in a variety of processes, including Fe metabolism, eosinophil differentiation, and plasminogen activation. Considering the vital role of Fe in many metabolic pathways, such as DNA and heme synthesis, it is important to understand the function of MTf. To defin...

Melanoma tumor antigen p97 or melanotransferrin (MTf) is an iron (Fe)-binding protein with high homology to serum transferrin. MTf is expressed at very low levels in normal tissues and in high amounts in melanoma cells although its function remains elusive. To understand the function of MTf, we utilized whole-genome microarray analysis to examine the gene expression profile of five models after...

The expression of melanotransferrin (MTf), a membrane-bound glycoprotein highly expressed in melanomas, is correlated with tumor vascularization and progression, suggesting a proinvasive function associated with MTf in malignant tumors. To test this hypothesis, we silenced MTf in human melanoma SK-MEL-28 cells using small interfering RNA (siRNA) and examined the plasmin activity and invasivenes...

We consider the time-harmonic electromagnetic transmission problem for unit sphere. Appealing to a vector spherical harmonics analysis, we prove first stability result of local multiple traces formulation (MTF) electromagnetics, originally introduced by Hiptmair and Jerez-Hanckes (2012) acoustic case, paving way towards an extension general piecewise homogeneous scatterers. Moreover, investigat...

Metal activation of metallothionein gene transcription depends mainly on the presence of regulatory DNA sequences termed metal-regulatory elements (MREs) and involves MRE-binding transcription factor-1 (MTF-1) interacting with the MREs in a Zn(2+)-dependent manner. We previously identified and characterized a nuclear protein, termed metal element protein-1 (MEP-1), specifically binding with hig...

Although turbulence is usually considered to be the primary cause of image blur, simultaneous and independent measurements of overall atmospheric modulation transfer function (MTF) and turbulence MTF over fairly long horizontal paths at 15-m average elevation indicate that, even at midday, aerosol MTF deriving from forward scatter is usually more dominant than turbulence MTF. Three different ex...

Energy saving is major matter in our global world, and heat exchanger is very useful for energy saving. Of course heat exchanger is most significant component for chemical reaction, distillation, dissolution, crystallization, fermentation etc. So the correct selection of heat exchanger is important in these processes. Spiral tube Heat Exchangers are known as excellent heat exchanger because of ...