PURPOSE This study examines a patient with cone-rod dystrophy using high-resolution adaptive optics retinal imaging. Conventional ophthalmoscopes provide limited resolution due to their inability to overcome the eye's optical aberrations. In contrast, adaptive optics ophthalmoscopes correct these aberrations to provide noninvasive high-resolution views of the living retina. To date, adaptive op...

AIM To determine the anatomical site and extent of electrophysiological dysfunction in patients with ethambutol associated visual loss. METHODS A comparative case series. Four patients with ethambutol associated visual loss underwent multifocal electroretinography (mERG). Two patients had advanced visual loss while two had early signs of toxicity. The N1-P1, N1, P1 amplitudes, N1, and P1 late...

Abstract Background Female-limited early-onset high myopia, also called Myopia-26 is a rare monogenic disorder characterized by severe short sightedness starting in early childhood and progressing to blindness potentially the middle ages. Despite X-linked locus of mutated ARR3 gene, disease paradoxically affects females only, with males being asymptomatic carriers. Previously, this has only bee...

A 1-year-old Australian Shepherd (AS) was presented for a routine hereditary eye examination. During the examination multiple raised, brown to orange lesions were noted in the fundus, which could not be attributed to a known retinal disease in this breed. As they clinically most closely resembled canine multifocal retinopathy (cmr) and no indication of an acquired condition was found, genetic t...

The electrical response of the retina was examined as a function of retinal region, using stimuli of various spatial frequencies in the first experiment. In the second experiment, the regional response of the retina to defocus at high and low spatial frequencies was investigated. Twenty three subjects were recruited for global flash multifocal electroretinogram (mfERG) in experiment 1. Black an...

PURPOSE To determine the effects of aging on the first and second-order kernels of the multifocal electroretinogram (ERG). METHODS Multifocal ERGs were recorded from 52 healthy subjects (52 eyes) (0 >or= refractive error >or= -3.0 diopter). The ages of the subjects ranged from 12-76 years with a mean (+/-SD) of 44.0 +/- 20.2 years. The Visual Evoked Response Imaging System was used. The effec...

PURPOSE To study whether the Artifact Removal procedure available for eliminating artifacts in multifocal electroretinograms (mERG) works correctly or not. METHODS A test response was made using a photo-diode circuit. mERGs were recorded from 3 well-trained normal subjects using the Veris III system, and were then analyzed by the procedure that is included in the Veris Science (Artifact Remov...