نتایج جستجو برای: mucosal vaccines

تعداد نتایج: 87287  

2013
Eric A. Weaver Pramod N. Nehete Bharti P. Nehete Guojun Yang Stephanie J. Buchl Patrick W. Hanley Donna Palmer David C. Montefiori Guido Ferrari Philip Ng K. Jagannadha Sastry Michael A. Barry

Most HIV-1 infections are thought to occur at mucosal surfaces during sexual contact. It has been hypothesized that vaccines delivered at mucosal surfaces may mediate better protection against HIV-1 than vaccines that are delivered systemically. To test this, rhesus macaques were vaccinated by intramuscular (i.m.) or intravaginal (ivag.) routes with helper-dependent adenoviral (HD-Ad) vectors e...

Journal: :The Pediatric infectious disease journal 2002
Qibo Zhang Emily Pettitt Roger Burkinshaw Gillian Race Lynne Shaw Adam Finn

BACKGROUND Serogroup C meningococcal conjugate polysaccharide vaccines have been reported to induce significant serum IgG antibodies and immunologic memory in infants. Because meningococcus is a mucosal pathogen colonizing the nasopharynx, local mucosal immune responses may play an important role in host defense against infection and carriage. We have investigated the mucosal IgA and IgG antibo...

2017
Masahisa Hemmi Masashi Tachibana Natsuki Fujimoto Masaki Shoji Fuminori Sakurai Kouji Kobiyama Ken J. Ishii Shizuo Akira Hiroyuki Mizuguchi

Few current vaccines can establish antigen (Ag)-specific immune responses in both mucosal and systemic compartments. Therefore, development of vaccines providing defense against diverse infectious agents in both compartments is of high priority in global health. Intramuscular vaccination of an adenovirus vector (Adv) has been shown to induce Ag-specific cytotoxic T lymphocytes (CTLs) in both sy...

Journal: :Human vaccines 2010
Diana C Otczyk Allan W Cripps

Most infections occur at or through mucosal surfaces. Despite this knowledge, current vaccination practices rely predominantly on parenteral administration with only a few vaccines being registered for administion by the mucosal route. Whilst mucosal immunization brings many advantages, the lack of reliable delivery systems has been a major drawback to date. With the recent advances in delivery...

Journal: :Current Opinion in Immunology 2013

Journal: :Advanced drug delivery reviews 2015
Christopher J H Davitt Ed C Lavelle

While the majority of human pathogens infect the body through mucosal sites, most licensed vaccines are injectable. In fact the only mucosal vaccine that has been widely used globally for infant and childhood vaccination programs is the oral polio vaccine (OPV) developed by Albert Sabin in the 1950s. While oral vaccines against Cholera, rotavirus and Salmonella typhi have also been licensed, th...

2007
Jiri Mestecky Michael W. Russell Charles O. Elson

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