introduction: natural killer (nk) cells, of which cd56 is a specific marker, play an important role in host defense against tumors. cancer stem cells, of which aldehyde dehydrogenase isoform 1 (aldh1) is an immunohistochemical marker, are a group of tumorigenic cells which are involved in migration and tumor recurrences. we aimed to evaluate the expression of aldh1 and cd56 in common salivary g...

BACKGROUND Mucoepidermoid carcinoma of the trachea is a rare pediatric malignancy that presents unique challenges in diagnosis, operative management, and surveillance. METHODS AND RESULTS We present a 17-year-old girl with primary tracheal mucoepidermoid carcinoma presenting in acute respiratory distress due to near-total occlusion of the tracheal airway. An algorithmic approach to preoperati...

INTRODUCTION Sclerosing mucoepidermoid carcinoma with eosinophilia is a rare morphological variant of thyroid carcinoma associated with Hashimoto's disease. To date, only three such tumors have been reported in the minor salivary glands. We describe the first case, to the best of our knowledge, of recurrent sclerosing mucoepidermoid carcinoma with eosinophilia in the minor salivary glands of th...

BACKGROUND Patients with mucoepidermoid carcinoma exhibit poor long-term prognosis because of the lack of therapeutic strategies that effectively block tumor progression. We have previously characterized the Ms cells as a highly metastatic mucoepidermoid carcinoma cell line that expresses high levels of transforming growth factor β1 (TGF-β1). Here, we studied the effect of suppressing TGF-β1 by...

OBJECTIVE To determine clinical and histopathologic features of mucoepidermoid carcinoma of the parotid gland, specifically, the relation of tumor stage and grade and treatment type with clinical outcome. DESIGN Retrospective clinical and histopathologic review. SETTING Tertiary care medical center. PATIENTS From 1940 to 1994, 128 patients were treated at our institution for parotid mucoe...

Mucoepidermoid carcinoma (MEC) is the most frequent malignant salivary gland cancer. Response to chemoradiotherapy is modest, and therefore radical surgery remains the standard-of-care. Emerging evidence suggests that Interleukin (IL)-6 signaling correlates with the survival of cancer stem cells and resistance to therapy. Here, we investigated whether inhibition of IL-6 receptor (IL-6R) signali...

A 59-year-old man was admitted to our hospital with dyspnea and cough. A large polypoid tumor was observed in the lower trachea and bronchoscopic polypectomy was performed using a snare to relieve symptoms. The tumor was diagnosed as a high grade mucoepidermoid carcinoma mainly by the histology of piecemeal specimens obtained by bronchoscopic resection. The primary lesion involved the trachea a...

In this issue of Clinical Cancer Research , Okabe et al. (1) have analyzed 71 cases of mucoepidermoid cancer and 51 cases of non-mucoepidermoid cancer for the presence of the Mect1Maml2 fusion oncogene and have made a valuable observation. They confirmed that Mect1-Maml2 expression is specific for mucoepidermoid cancer and showed that fusion-positive tumors have histologic and prognostic featur...

In this issue of Clinical Cancer Research , Okabe et al. (1) have analyzed 71 cases of mucoepidermoid cancer and 51 cases of non-mucoepidermoid cancer for the presence of the Mect1Maml2 fusion oncogene and have made a valuable observation. They confirmed that Mect1-Maml2 expression is specific for mucoepidermoid cancer and showed that fusion-positive tumors have histologic and prognostic featur...