Multiple sclerosis is the most frequent demyelinating disease in the human CNS characterized by inflammation, demyelination, relative axonal loss and gliosis. Remyelination occurs, but is frequently absent or restricted to a small remyelinated rim at the lesion border. Impaired differentiation of oligodendroglial precursor cells is one factor contributing to limited remyelination, especially in...

MicroRNA expression profiles of patients with multiple sclerosis (MS) have revealed differences from healthy controls both in cells from the peripheral circulation and in specimens from white matter lesions. Here, we studied differences in microRNA expression and in their predicted mRNA targets in white and grey matter lesions of patients with MS as compared with white and grey matter brain tis...

OBJECTIVE Histologic examination of multiple sclerosis (MS) brain lesions reveals heterogeneity including the presence or absence of a central blood vessel. Recent work has shown that T2* weighted magnetic resonance imaging at 7T allows the identification of small parenchymal veins within MS lesions. The aims of this study were (1) to compare whether a comparable sequence at 3T was also capable...

Multiple sclerosis (MS) has long been considered to be the autoimmune disease that primarily affects oligodendrocyte and myelin in the white matter (WM) of the CNS. However, renewed interest in the gray matter (GM) pathology including cortical and deep GM of MS is emerging. Radiological and pathological assessments demonstrate that substantial cortical demyelination is prominent in all stages o...

Background: Multiple Sclerosis (MS) is a degenerative disease of central nervous system. MS patients have some dead tissues in their brains called MS lesions. MRI is an imaging technique sensitive to soft tissues such as brain that shows MS lesions as hyper-intense or hypo-intense signals. Since manual segmentation of these lesions is a laborious and time consuming task, automatic segmentation ...

Objective: Measurement of blood-brain permeability dysfunction in active and chronic MS lesions with T1-weighted dynamic contrast-enhanced MRI to show variation in inflammatory activity Background: blood-brain-barrier perfusion characterization impaired in MS as some studies have shown recently buta comparison between perfusion parameters in contrast-enhanced and non-enhanced lesions not have ...

Several important questions about the early stages of the pathophysiology of multiple sclerosis (MS) are currently unresolved. Some of these questions include the relative importance of central versus peripheral mechanisms in initiating lesion formation; whether MS begins with myelinforming cells or immune cells; whether lesions are relatively heterogeneous or homogeneous; and the role of axona...

In the present study, the effect of the medial septal (MS) lesions on exploratory activity in the open field and the spatial and object recognition memory has been investigated. This experiment compares three types of MS lesions: electrolytic lesions that destroy cells and fibers of passage, neurotoxic - ibotenic acid lesions that spare fibers of passage but predominantly affect the septal nonc...

BACKGROUND AND PURPOSE Magnetization-transfer imaging is a technique that could provide indirect evidence of the characteristics of multiple sclerosis (MS) lesions. The purpose of this work was to study the evolution of MS lesions on T1-weighted MR images over time and to investigate changes in magnetization-transfer ratio (MTR) values of MS lesions with different initial appearances on contras...