Abstract Background Radiation-induced myelopathy is a severe and irreversible complication that occurs after long symptom-free latency time if the spinal cord was exposed to significant irradiation dose during tumor treatment. As carbon ions are increasingly investigated for treatment in clinical trials, their effect on normal tissue needs further investigation assure safety of patient treatmen...

UNLABELLED The combination of small-animal PET and MRI data provides quantitative in vivo insights into cardiac pathophysiology, integrating information on biology and morphology. We sought to determine the feasibility of PET and MRI for the quantification of ischemic injury in the rat model. METHODS Fourteen healthy male Wistar rats were studied with 18F-FDG PET and cine MRI. Myocardial viab...

Purpose: Commonly used diffusion weighted (DW) imaging such as DW spin echo (SE) type echo planar imaging (DW-SE-EPI) is known to be a snapshot-like acquisition and to have a relatively high signal-to-noise ratio. Spiral MRI sequence (SPIRAL) has characteristics similar to these of EPI, but it has rarely been used for diffusion-weighted imaging (DWI). In vivo DW-SPIRAL of the rat brain has almo...

Miniature rat Ishikawa (MRI) is an experimental model for pituitary miniaturism with an autosomal recessive mode of inheritance. This paper reports the discovery and initial characterization of a new mutant rat. The mutation arose spontaneously in a breeding colony of Wistar rats at the Ishikawa Animal Laboratory (Saitama). Body growth in MRI was retarded in 56% and 71% of normal control rats f...

Simultaneously acquired EEG and BOLD (Blood Oxygenation level dependent contrast) MRI allowed to study on line the neurophysiological changes in rat brain during epileptic seizures. MRI and EEG data were acquired with a specially designed high quality MR RF-antenna with incorporated non-invasive carbon EEG electrodes. The problem of severe pollution of the EEG data due to MR gradient switching ...

MRI provides a sensitive and specific imaging tool to detect acute ischemic stroke by means of a reduced diffusion coefficient of brain water. In a rat model of ischemic stroke, differences in quantitative T1 and T2 MRI relaxation times (qT1 and qT2) between the ischemic lesion (delineated by low diffusion) and the contralateral non-ischemic hemisphere increase with time from stroke onset. The ...

Over the last decade, several papers have focused on the construction of highly detailed mouse high field magnetic resonance image (MRI) templates via non-linear registration to unbiased reference spaces, allowing for a variety of neuroimaging applications such as robust morphometric analyses. However, work in rats has only provided medium field MRI averages based on linear registration to bias...

OBJECTIVE To explore the migration of transplanted neural stem cells co-labeled with superparamagnetic iron oxide (SPIO) and bromodeoxyuridine (Brdu) using the 4.7T MR system and to study the cell differentiation with immuno-histochemical method in ischemic rats. METHODS Rat neural stem cells (NSCs) co-labelled with SPIO mediated by poly-L-lysine and bromodeoxyuridine (BrdU) were transplanted...

An in vivo MRI study employing a high field (7T) magnet and a T1- and T2-weighted imaging sequence with subsequent histopathological evaluations was undertaken to develop and evaluate MRI-based volumetric measurements in the rat. The brain structures considered were the hippocampus, the cingulate cortex, the retrosplenial granular cortex and the ventricles. Control (n=3) and kainic acid (KA; n=...