Poly (lactic-co-glycolic acid) nanoparticles (PLGA NPs) have been considerably studied as a promising biodegradable delivery system to induce effective immune responses and to improve stability, safety, and cost effectiveness of vaccines. The study aimed at evaluating early inflammatory effects and cellular safety of PLGA NPs, co-encapsulating ovalbumin (PLGA/OVA NPs), as a model antigen and th...

Visceral leishmaniasis (VL) persists as a major public health problem, and since the existing chemotherapy is far from satisfactory, development of an effective vaccine emerges as the most appropriate strategy for confronting VL. The development of an effective vaccine relies on the selection of the appropriate antigen and also the right adjuvant and/or delivery vehicle. In the present study, t...

Strategies to design delivery vehicles are critical in modern vaccine-adjuvant development. Nanoparticles (NPs) encapsulating antigen(s) and adjuvant(s) are promising vehicles to deliver antigen(s) and adjuvant(s) to antigen-presenting cells (APCs), allowing optimal immune responses against a specific pathogen. In this study, we developed a novel adjuvant delivery approach for induction of effi...

Author(s) Kobayashi, Tatsuo; Seto, Osamu Citation Modern Physics Letters A, 30(21): 1550106 Issue Date 2015-07-10 Doc URL http://hdl.handle.net/2115/62383 Right Electronic version of an article published as Modern Physics Letters A, Volume 30, Issue 21, 2015, 1550106 (11 pages) DOI: 10.1142/S0217732315501060 © copyright World Scientific Publishing Company http://www.worldscientific.com/worldsci...

Vaccines formulated with nonreplicating pathogens require adjuvants to help bolster immunogenicity. The role of adjuvants in Ab production has been well studied, but how they influence memory CD8(+) T cell differentiation remains poorly defined. In this study we implemented dendritic cell-mediated immunization to study the effects of commonly used adjuvants, TLR ligands, on effector and memory ...

Visceral leishmaniasis, caused by Leishmania (L.) donovani and L. infantum protozoan parasites, can provoke overwhelming and protracted epidemics, with high case-fatality rates. An effective vaccine against the disease must rely on the generation of a strong and long-lasting T cell immunity, mediated by CD4+ TH1 and CD8+ T cells. Multi-epitope peptide-based vaccine development is manifesting as...

A caracterização politico-ideológica e a análise dos movimentos nacionalistas An The political-ideological characterization and analysis of Angolan nationalist movements the conflicts between them, has always been subject major passionate political-academic discussion, which became an important component movements’ international domestic definition. MPLA (Popular Movement for Liberation Angola)...