To clarify the way in which the clinical response to levodopa changes with the progression of Parkinson's disease, a longitudinal study was performed to quantify motor response characteristics to single doses of levodopa by mouth over three years in 23 patients with fluctuating motor function. A significant increase in motor disability in "on" (time of peak motor improvement) and "off" (before ...

AIM Upper extremity paresis is a leading cause of disability after stroke. A Cochrane review found an impact on disability of Constraint-Induced Movement Therapy (CIMT), its modified forms (mCIMT) and Forced Use (FU), with a moderate significant effect and a large significant effect on arm motor function. This article aims to present an update of the Cochrane review and assess the effects of CI...

BACKGROUND High-frequency stimulation of the subthalamic nucleus (STN) is an effective treatment for advanced forms of Parkinson disease. Postoperative improvement of motor parkinsonian disability is known to depend on patient selection and surgical targeting. OBJECTIVE To determine which clinical and electrophysiological variables evaluated during the operation predict the postoperative clin...

OBJECTIVE To study the effects of general anesthesia on the postoperative outcome of patients with Parkinson disease (PD) who underwent surgery using bilateral placement of stimulating electrodes within the subthalamic nucleus (STN). DESIGN Retrospective analysis. SETTING Hôpital de la Salpêtrière, Paris, France. PATIENTS Fifteen PD patients who underwent bilateral implantation of electro...

Background: The aim of present study was to determine the influence of stress management on affective control and distress tolerance in mothers of children with sensory-motor disabilities. Methods: This current study was a study with pretest-posttest and treatment group. The thirty mothers of children with sensory-motor disabilities were selected from sensory-motor disabilities center in Qum...

BACKGROUND although non-motor symptoms of Parkinson's disease (PD) are known to adversely affect disability and health-related quality of life, the impact that specific disorders of reward and motivation have remains unclear. Impulse control disorders are more likely in those with a younger disease onset although there is no strong evidence to date that apathy is related to age of onset or corr...

OBJECTIVE To determine whether specifically designed activities of daily living (ADL) observations can measure disability due to apraxia with more sensitivity than the Barthel ADL Index, a conventional functional scale. DESIGN Cross-sectional study. SETTING Rehabilitation centres and nursing homes. SUBJECTS One hundred and six left hemisphere stroke patients with apraxia, hospitalized in ...