نتایج جستجو برای: morphine sensitization

تعداد نتایج: 32486  

Journal: :physiology and pharmacology 0
hamidreza famitafreshi department of physiology, tehran university of medical science- international campus, tehran, iran morteza karimian department of physiology, tehran university of medical science, tehran, iran

introduction: abusing drugs such as morphine continues to be a serious medical and social problem. defining a habit that increases the devastating effect such as compulsive use and craving is necessary. methods: this experiment was designed in four groups 1) group-housed (gh) 2) isolation 3) group-housed morphine-treated (ghmt) (4) isolated-housed morphine-treated (ihmt). rats were received mor...

A Eidi H Ghoshooni H Sahraei L Etemadi M Eidi S Oryan

Repeated administration of morphine sensitizes animals to the stimulant and rewarding properties of the drug. It may also alter the expression and function of GABA receptors within the ventral tegmental area (VTA), a midbrain region that is implicated in morphine action. In the present study, the effect of activation of GABAB receptor subtypes within the VTA on morphine-induced incentive sensit...

A Eidi H Ghoshooni H Sahraei L Etemadi M Eidi S Oryan

Repeated administration of morphine sensitizes animals to the stimulant and rewarding properties of the drug. It may also alter the expression and function of GABA receptors within the ventral tegmental area (VTA), a midbrain region that is implicated in morphine action. In the present study, the effect of activation of GABAB receptor subtypes within the VTA on morphine-induced incentive sensit...

2017
Firoozeh Alavian Saeedeh Ghiasvand Hedayat Sahraei Maryam Rafiei-Rad

Background The amygdala is one of the nerve centers involved in drug reward. It is suggested that the central nucleus of the amygdala (CeA) is involved in morphine dependency. The CeA gamma-aminobutyric acid-ergic (GABAergic) system is a mediator of morphine rewarding effects. In this research, the effects of stimulation or inhibition of CeA GABA type B (GABAB) receptors on sensitization acquis...

Journal: :Progress in Neuro-Psychopharmacology and Biological Psychiatry 2015
Eduardo A.V. Marinho Alexandre J. Oliveira-Lima Renan Santos André W. Hollais Marilia A. Baldaia Raphael Wuo-Silva Thais S. Yokoyama André L. Takatsu-Coleman Camilla L. Patti Beatriz M. Longo Laís F. Berro Roberto Frussa-Filho

RATIONALE The endocannabinoid system has been implicated in the neurobiological mechanism underlying drug addiction, especially the primary rewarding dopamine-dependent processes. Therefore, endocannabinoid receptor antagonists, such as the CB1 cannabinoid antagonist rimonabant, have been proposed as candidates for preventive addiction therapies. OBJECTIVES Investigate the possible involvemen...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2003
Shoshana Eitan Camron D Bryant Nazli Saliminejad Yu C Yang Elroy Vojdani Duane Keith Roberto Polakiewicz Christopher J Evans

Opioid-receptor activation in cell lines results in phosphorylation of p42/44 mitogen-activated protein kinase (MAPK), which contributes to agonist-induced desensitization of adenylate cyclase signaling. In this study, morphine-induced MAPK modulation was examined in the mouse brain using antibodies against phosphorylated MAPK. Thirty minutes after systemic morphine, MAPK modulation was observe...

Journal: :Molecular pharmacology 2000
M Yoshimura P H Wu P L Hoffman B Tabakoff

The mechanisms by which morphine-induced analgesia and tolerance and physical dependence on morphine arise have been the subject of intense study, and much work has pointed to the involvement of cAMP-mediated events in the neuroadaptive phenomena leading to morphine tolerance and/or dependence. We overexpressed an opioid receptor-stimulatable form of adenylyl cyclase (type 7) in the central ner...

Introduction: Abusing drugs such as morphine continues to be a serious medical and social problem. Defining a habit that increases the devastating effect such as compulsive use and craving is necessary. Methods: This experiment was designed in four groups 1) group-housed (GH) 2) isolation 3) group-housed morphine-treated (GHMT) (4) isolated-housed morphine-treated (IHMT). Rats were received mor...

Journal: :Research results in pharmacology 2022

Introduction: Nociceptive stimulus triggers escape responses in Drosophila melanogaster larvae, characterized by 360° rolling behavior along its own body axis. Therefore, it is possible to study analgesic drugs based on this stereo­typical nociceptive-like behavior. Here, we aimed develop an predictive validity test of thermal nociception through D. larvae.
 Materials and methods: We evalu...

Azam Bakhtiarian, Fatemeh Farokhi, Hassan Ghoshooni, Hedayat Sahraei, Jamal Shams, Seyed Said Pournaghash Tehrani, Seyedeh Maedeh Fatemi,

Introduction: Topiramate is a newly anti-convulsant drug, which acts as NMDA glutamate receptor antagonist as well as the GABAB receptor agonist. It is used for physical dependence to opioids as well as cocaine, nicotine, alcohol and ecstasy dependence. In the present study attempts were made to further identification of the effects of topiramate on the acquisition and expression of morphine...

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