Morphea is a rare fibrosing disorder of the skin and underlying tissues. Circumscribed morphea presents with less than three discrete indurated plaques and breasts are commonly affected in women. We report the case of a 12-year-old female with a right infra-areolar, nontender, brownish patch and asymmetry of the right breast with 2 years of evolution. Skin biopsy showing thickening of the derma...

Morphea is one of diseases characterised by fibrosis of the skin and subcutaneous tissue. It is a chronic disease that does not shorten the life of the patient, yet significantly affects its quality. The group of factors responsible for its pathogenesis is thought to include disturbed functioning of endothelial cells as well as immune disturbances leading to chronic inflammatory conditions, acc...

Objective: Localized scleroderma (LS), which is also called as morphea, a rare skin disease with unknown etiology. LS typically characterized by sclerosis in the dermis and subcutaneous tissue. The number of retrospective studies examining epidemiological, clinical laboratory data patients juvenile Turkey very limited. purpose this study was to investigate demographic characteristics pediatric ...

Both morphea and lichen sclerosus et atrophicus (LSA) are connective tissue diseases that mainly affect the skin. A recent report suggested that a substantial portion of morphea coexists with LSA. In this report, we describe a case of LSA on the abdomen accompanied by morphea; we employed immunohistochemical staining for periostin as well as MMP-7 and MMP-28, both of which are reported to facil...

L ocalized scleroderma (also called morphea) can be classified into several subtypes: generalized, plaque-type, bullous, linear, and deep morphea. In addition, eosinophilic fasciitis can be distinguished from these. It is important to know more about the prevalence and severity of the frequently reported symptoms of itch, pain, and fatigue to develop guidelines for managing sclerotic skin disea...

Two siblings had hyperpigmented indurations over the inner aspects of both thighs extending to the lower abdomen. Skin biopsy showed plasma cell panniculitis favoring a diagnosis of morphea profundus. Family history of consanguinity was present, but both parents were unaffected. To our knowledge this is the first report of autosomal recessive plasma cell panniculitis with the clinical manifesta...

Localized scleroderma is a connective tissue disorder generally involving de entire dermis and usually limited to the subcutaneous tissue; however, it may progress to large indurated plaques, growth retardation, muscle atrophy, and even to flexion deformities or poorly healing ulcers. Unilateral generalized morphea is an extremely rare variant of localized scleroderma which has seldom been repo...

BACKGROUND Morphea, also known as localized scleroderma, is a rare autoimmune connective tissue disease characterized by skin fibrosis. UVA1 phototherapy is an important asset in the reduction of clinical manifestations in morphea. There are studies claiming that UV light modulates the expression of some human endogenous retroviral sequences. The aim of this study was to determine if the expres...

Breast cancer is the most common cancer in women of developed countries. Early stage diagnosis is followed, in many cases, of conservative surgery and local radiotherapy. This treatment reduces loco-regional recurrences but may be accompanied by local complications. Morphea of the breast is an uncommon skin condition and has been described after radiotherapy. The inflammatory stage of morphea c...