Background: Isfahan is one of the major foci of cutaneous leishmaniasis in Iran. According to the epidemiological studies, both urban and rural forms have been reported in Isfahan. Accurate identification and characterization of Leishmania is essential for the control of the disease. Several different molecular techniques for Leishmania identification are developed including use of monoclonal a...

SARS-CoV-2 can escape natural immune responses, but the virus evade monoclonal antibodies and vaccine-mediated immunity?

A murine IgM monoclonal antibody (MA-2C6) with κ-light chains directed against an antigenic determinant of outer surface protein A (OspA) of the Lyme disease spirochete, Borreliaburgdorferi, is produced. This antibody could bind specifically to OspA antigen of several isolates of B. burgdorferi, but not to the non-Lyme disease bacteria such as T. pallidum and B. hermsii. Antibody MA-2C6 was pur...

Background:  Cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) molecules are expressed on T-cells and inhibit their function by inhibiting activation of subsequent T-cell molecular pathways. Blocking of CTLA-4 inhibits the growth of malignant tumor cells. Anti-CTLA-4 monoclonal antibodies activate the immune system against cancer. Due to several advantages of single-chain antibodi...

Evaluation of the Adverse Effects Monoclonal Antibodies in Breast Cancer Treatment a Tertiary Care Hospital Bengaluru, India, 2020

the principle of cancer immunotherapy includes various methods of manipulations to influence immune responses against tumors in both humans and animals. this advanced technology of hybridoma production provided the necessary skills to efficiently produce highly specific monoclonal antibodies (mab). radioactively-tagged antibodies which are applied in radioimmunotherapy (rit), can target adjacen...

Background: To evaluate the efficacy of different pharmacological interventions, with emphasis on monoclonal antibodies (McAbs) for treatment postmenopausal osteoporotic women.

introduction: the present study was undertaken to produce alkaline phosphatase anti- alkaline phosphatase (apaap) complex and to use it in one of the most practical methods of determining the site of antigen in tissue or in cell, i.e. apaap technique, and its comparison with similar foreign products. materials and methods: in this basic and applied study the secreted antibodies of the two hybri...

in recent years, recombinant monoclonal antibodies and their derivatives have emerged as important targeted therapy agents. monoclonal antibodies are ex-tremely difficult to produce. so, the cost of production is very high and many people cannot afford these drugs. in this regard, choosing inexpensive and easy ways to manipulate production systems such as bacterial hosts to reduce the cost of m...