One of several features acquired by chromatin of the inactive X chromosome (Xi) is enrichment for the core histone H2A variant macroH2A within a distinct nuclear structure referred to as a macrochromatin body (MCB). In addition to localizing to the MCB, macroH2A accumulates at a perinuclear structure centered at the centrosome. To better understand the association of macroH2A1 with the centroso...

Gestational infection is increasingly being recognized for its involvement as causative mechanism in severe developmental brain abnormalities and its contribution to the pathogenesis of psychopathologies later in life. First observations in the widely accepted maternal immune activation (MIA) model based upon the systemic administration of the viral mimetic Polyinosinic:polycytidylic acid (poly...

Abstract Background New anti-malarial therapeutics are required to counter the threat of increasing drug resistance. Malaria volunteer infection studies (VIS), particularly induced blood stage malaria (IBSM) model, play a key role in accelerating development. Supply reference 3D7-V2 Plasmodium falciparum cell bank (MCB) is limited. This study aimed develop new MCB, and compare safety infectivit...

Gaseous monochlorobenzene was irradiated with KrF excimer laser (248 nm) under reduced pressure. The photodecomposition was an apparent first order reaction. When the system contained no additive gas, the photolysis was found to give benzene (conversion yield: 49%) in the gas phase and many unidentified products in the solid phase. On the other hand, in the presence of oxygen, carbon dioxide (1...

Megaproject citizenship behavior (MCB) has been confirmed to a play vital role on megaproject performance. Although current research argued that institution elements have had an impact MCB diffusion, limited studies empirically investigated the distinct effectiveness of various driving MCB’s widespread diffusion in construction megaprojects. Based theory, this study proposes theoretical model c...

Dehalobacter sp. strain TeCB1 was isolated from groundwater near Sydney, Australia, that is polluted with a range of organochlorines. The isolated strain is able to grow by reductive dechlorination of 1,2,4,5-tetrachlorobenzene to 1,3- and 1,4-dichlorobenzene with 1,2,4-trichlorobenzene being the intermediate daughter product. Transient production of 1,2-dichlorobenzene was detected with subseq...

In this study the term moisture conveyor belt (MCB) is defined as an elongated band of enhanced poleward water vapor fluxes (WVFs) above the PBL that is rooted in the Tropics. This new terminology is illustrated through an exemplary detailed case study of an MCB over the northeastern Pacific during 9–13 November 2003 that provides the moisture for a significant precipitation event in the dry so...

Characteristic membranous bodies have been previously reported in the cytoplasm of the cerebral neurons in Tay-Sachs disease (1) (Fig. 1). Subsequently (2) these lamellated particles were isolated from homogenized autopsy tissue by differential and density gradient centrifugation and subjected to extensive chemical analysis. The membranous cytoplasmic bodies (MCB) were found to consist of about...

The general principle behind the marine cloud brightening (MCB) climate engineering technique is that seeding marine stratocumulus clouds with substantial concentrations of roughly monodisperse sub-micrometre-sized seawater particles might significantly enhance cloud albedo and longevity, thereby producing a cooling effect. This paper is concerned with preliminary studies of the possible benefi...

OBJECTIVE To determine an unusual complex chromosome rearrangement found in a man with oligospermia with a normal phenotype. DESIGN Case report with a review of the literature. SETTING Academic research environment. PATIENT(S) A man with oligospermia but otherwise apparently healthy. INTERVENTION(S) Peripheral blood lymphocytes were used for karyotyping, and metaphases were analyzed by ...