Surface-enhanced Raman spectroscopy (SERS) is a promising tool in the analytical science because it provides good selectivity and sensitivity without the labeling process required by fluorescence detection. This technique consists of locating the target analyte on nanometer range of roughed Au-nanoparticles. The presence of the metal nanoparticles provides a tremendous enhancement to the result...

Introduction The membrane-associated form of heat shock protein 70 (Hsp70) represents a promising target for fluorescence-based intraoperative molecular imaging. Contrary to normal tissue cells, Hsp70 is selectively upregulated on the plasma membrane many tumor entities, including HNSCC.We investigated whether topical application fluorescence-labeled peptide tracer (TPP-IRDye800), that specific...

The full harvesting of both singlet and triplet excitons can pave the way toward more efficient molecular light-emission mechanisms (i.e., TADF or thermally activated delayed fluorescence) beyond t...

The impact of the molecular design on observable thermally activated delayed fluorescence is discussed for three compounds consisting a dihydrophenazine donor core and differently substituted benzonitrile acceptor units.

We report on a study that combines advanced fluorescence methods with molecular dynamics simulations to cover timescales from nanoseconds milliseconds for large protein, the chaperone Hsp90.