Genetic background affects the susceptibility to mammary tumor development in Apc(Min/+) mice. Here we report the identification of four novel modifier loci that influence different aspects of mammary tumor development in Apc(Min/+) mice. Analysis of tumor development in a backcross of (FVBB6 Apc(Min/+)) x B6 Apc(Min/+) mice has identified a modifier on chromosome 9 that significantly affects t...

Modifying the surfaces of metal nanoparticles with self-assembled monolayers of functionalized thiols provides a simple and direct method to alter their surface properties. Mixed self-assembled monolayers can extend this approach since, in principle, the surfaces can be tuned by altering the proportion of each modifier that is adsorbed. However, this works best if the composition and microstruc...

The thermo-optic coefficient (dn/dT) of inorganic–organic hybrid material films prepared by the sol-gel process of organoalkylsilanes is measured using a prism coupler equipped with a hot stage. The effect of the organic modifier on the variation of dn/dT in inorganic–organic hybrid material films has been investigated. The value of dn/dT becomes more negative with increasing molecular weight o...

This study investigates the properties of a durative modifier that exclusively targets result states in Turkish. We call this RSM, standing for Result State Modifier. What is peculiar about RSM it can express actual duration state, as well non-actual an state. Our goal to describe conditions under which these two interpretations are licensed and provide compositional analysis how derived. argue...

The retention factor is the key quantity for thermodynamic analysis of mechanism in chromatographic experiments. In this work, we measure factors moderately polar solutes on four silica-based porous matrices as stationary phases by supercritical fluid chromatography. Elution only possible with binary mixtures carbon dioxide (sc-CO2) and modifier (methanol) due to low polarity pure sc-CO2. addit...

The combination of two existing words is a productive strategy used by speakers to convey new concepts and extend the limits of their vocabulary. In English compounds, the first word or modifier attaches further meaning to the second word or head, thus creating a reference to the intended concept. According to Gagné and Shoben’s (1997) Competition Among Relations In Nominals (CARIN) theory, the...

Since its discovery in 1981, ubiquitin-activating enzyme 1 was thought to be the only E1-type enzyme responsible for ubiquitin activation. Recently, a relatively uncharacterized E1 enzyme, designated ubiquitin-like modifier activating enzyme 6, was also shown to activate ubiquitin. Ubiquitin-activating enzyme 1 and ubiquitin-like modifier activating enzyme 6 are both essential proteins, and eac...

Genetic evidence suggests that the evolution of resistance to the insecticide diazinon in Lucilia cuprina initially produced an increase in asymmetry. At that time resistant flies were presumed to be at a selective disadvantage in the absence of diazinon. Subsequent evolution in natural populations selected modifiers to ameliorate these effects. The fitness and fluctuating asymmetry levels of r...

If constantly changing genotypes are favorable in host and parasite coevolution, an indefinite escalation of mutation rates would result despite heavy mutational loads. We theoretically study this possibility by examining the mutation modifier dynamics of host and parasite that engage in genotype-specific epidemiological interaction. In the first model, we study the evolutionarily stable (ESS) ...

in this work, we report, optical properties of cd1-xsnxte quantum dots (x= 0.05, 0.10 and 0.15) synthesized in water using thioglycolic acid (tga) as a modifier agent. the optical characterization of the samples was performed through absorption (uv) and photoluminescence spectra (pl). a red shift absorption and fluorescent emission peaks was observed which can be related to the increase of nano...