Three modified 20-mer antisense oligonucleotides targeted to human intercellular adhesion molecule-1 mRNA were characterized for their presystemic stability and oral bioavailability compared with a first-generation phosphorothioate oligodeoxynucleotide (PS ODN), ISIS 2302. The three modified oligonucleotides contained 2'-O-(2-methoxyethyl) (2'-O-MOE) ribose sugar modifications on a portion, or ...

Objectives The pathophysiology of perihaematomal oedema (PO) surrounding a primary intracerebral haemorrhage (ICH) is complicated and incompletely understood. We prospectively investigated the components of PO with voxel-based analysis of the apparent diffusion coefficient (ADC) value and assessed its predictive value for functional outcome. Design Forty-six patients with ICH who were enrolled...

The reliability of implantable blood sensors is often hampered by unspecific adsorption of plasma proteins and blood cells. This not only leads to a loss of sensor signal over time, but can also result in undesired host vs. graft reactions. Within this study we evaluated the hemocompatibility of isocyanate conjugated star shaped polytheylene oxide-polypropylene oxide co-polymers NCO-sP(EO-stat-...

objective(s)cpg oligodeoxynucleotides (cpg odns) have been shown to have potent immunostimulatory adjuvant activity for a wide range of antigens. due to susceptibility of phosphodiester cpg odns (po cpg) to nuclease degradation, nuclease-resistant phosphorothioate cpg odns (ps cpg) were currently utilized in an in vivo model. in this study, according to some recently reported drawbacks with ps ...

An efficient wide-band analysis that combines modified integral equation-physical optics (IE-PO) hybrid formulation with the best uniform approximation is proposed for antennas around an electrically large platform in this paper. The modified single-level Fast Fourier Transform (FFT) algorithm which is based on the subdomain FFT acceleration is employed by interpolating the Green’s function and...

in (golchin a. and rezaei p., subpullbacks and flatness properties of s-posets. comm. algebra. 37: 1995-2007 (2009)) study was initiated of flatness properties of right -posets  over a pomonoid  that can be described by surjectivity of  corresponding to certain (sub)pullback diagrams and new properties such as  and  were discovered. in this article first of all we describe po-flatness propertie...

‎In this paper we take $mathcal A$ to be the category {bf Pos-S}‎ ‎of $S$-posets‎, ‎for a posemigroup $S$‎, ${mathcal M}_{pd}$ to‎ ‎be the class of partially ordered sequantially-dense‎ ‎monomorphisms and study the categorical properties‎, ‎such as‎ ‎limits and colimits‎, ‎of this class‎. ‎These properties are usually‎ ‎needed to study the homological notions‎, ‎such as injectivity‎, ‎of‎ ‎$S$-...