BACKGROUND AIB1 (SRC-3) is an estrogen receptor (ER) coactivator that, when overexpressed in cultured cells, can reduce the antagonist activity of tamoxifen-bound ERs. Signaling through the HER-2 receptor pathway activates AIB1 by phosphorylation. To determine whether high AIB1 expression alone or together with HER-2 reduces the effectiveness of tamoxifen in breast cancer patients, we quantifie...

Deriving clinical utility from large genomic datasets requires the identification of statistically significant associations between genomic measurements and a clinical phenotype. An important instance of this problem is to identify genetic variants that distinguish patients with different survival time following diagnosis or treatment. The most widely used statistical test for comparing the sur...

Model Suppose a set G of genes was sequenced in a collection P of patients, all of whom have the same disease. Each sequenced gene2 g ∈ G partitions the set of patients into two subsets: the P(g), with patients with a mutation in g, and the P̄(g), with patients with no mutation in g. The goal is to identify genes whose mutational status is highly correlated with the survival time, in the sense t...

This paper presents and statistically compares eight alternative methods that could possibly be used in the analysis of matched or paired sample data, including situations in which the data being analyzed satisfy the usual assumptions of normality and continuity necessary for the use of parametric tests as well as when the data are numeric and non-numeric measurements on as low as the ordinal s...

In Semantic Role Labeling (SRL), it is reasonable to globally assign semantic roles due to strong dependencies among arguments. Some relations between arguments significantly characterize the structural information of argument structure. In this paper, we concentrate on thematic hierarchy that is a rank relation restricting syntactic realization of arguments. A loglinear model is proposed to ac...

background: toxoplasma gondii infection is widely prevalent in many species of warm-blooded animals including human. the aim of this study was to determine the prevalence of antibodies to t. gondii from slaughtered sleep and goats by mod­ified agglutination test (mat) in kerman region , southeastern iran. methods : altogether 1340 blood samples were collected from 562 sheep and 778 goats from a...