the nonlinear static procedures (nsps) proposed by design codes do not lead to reliable results especially for tall buildings. they generally provide inconsistent estimates of inelastic seismic demands, especially for the top floors due to their inabilities in considering the higher modes effects. in this paper, a new enhanced pushover procedure is proposed which is based on the envelope of the...

Seven strains of HeLa cells have been characterized by the number of chromosomes and the activity of the enzymes alkaline phosphatase, glucose-6-phosphate dehydrogenase, 6-phosphogluconic dehydrogenase, and lactic dehydrogenase. All seven strains were found to differ as to chromosome numbers and enzyme levels despite the fact that two strains were called HeLa and three were called HeLa S3. Thre...

for the first time in the history of logic, abd al razzaq al-jili (d. 570/1174), in the treatise al-lame fi al-shakl al-rabe, dealt with the modal syllogisms of the fourth figure. previous to him, dinha, the priest, and ibn salah al-hamadani had discussed the non-modal moods of the fourth figure. jili’s treatise deals only with simple modalities and ignores the complex ones. his pupil, fakhr al...

Analysis of single-subject transcriptome response data is an unmet need of precision medicine, made challenging by the high dimension, dynamic nature and difficulty in extracting meaningful signals from biological or stochastic noise. We have proposed a method for single subject analysis that uses a mixture model for transcript fold-change clustering from isogenically paired samples, followed b...

A typical current study investigating the neurobiology of animal behavior is likely restricted to male subjects, of standard inbred mouse strains, tested in simple behavioral assays under laboratory conditions. This approach enables the use of advanced molecular tools, alongside standardization and reproducibility, and has led to tremendous discoveries. However, the cost is a loss of genetic an...

Two cell lines, one proficient (Mex+) and one deficient (Mex~) in the ability to remove 06-methylguanine, have been isolated by Epstein-Barr virus-mediated transformation of a single blood sample obtained from a normal human male. Extracts of un treated cells differ in their O6-methylguanine transferase (methyl acceptor protein) activity. Although both lines arise from the same individual, they...