Population: 173 people (mean age 33 years, 55% male) were consecutively recruited within 72 hours of psychiatric hospitalisation for manic (75%) or mixed (25%) episode bipolar disorder (DSM-IV criteria). Exclusions: current substance withdrawal, delirium, previous psychiatric hospitalisation unless for detoxification only, documented IQ ,70, ill for .1 year, previous treatment with a mood stabi...

PURPOSE Patients with a bipolar I disorder (BD-I) manic episode meeting the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5), criteria for "with mixed features" have a high incidence of suicide attempts and of anxiety, irritability, and agitation (AIA) symptoms. The aim of this analysis was to explore the relationship between suicidality and AIA symptoms in patients ...

OBJECTIVE Since improved prediction of illness course early in bipolar disorder is required to guide treatment planning, the authors evaluated recovery, first recurrence, and new illness onset following first hospitalization for mania. METHOD Bipolar disorder patients (N=166) were followed 2-4 years after their first hospitalization for a manic or mixed episode to assess timing and predictors...

In this large study, the patients were divided into three groups of acquired hyponatremia, always normal sodium, and acquired hypernatremia according to their first episode of SD after arrival in the ICU. The categorization of the patients based on the first episode of SD, although simple and informative, we think oversimplifies a complex and common disorder in the ICU. Critically ill patients ...

OBJECTIVE The authors compared the efficacy and safety of aripiprazole, a novel antipsychotic, to placebo for treatment of patients in an acute manic or mixed episode of bipolar disorder. METHOD This 3-week, multicenter, double-blind study randomly assigned 262 bipolar disorder patients in an acute manic or mixed episode to aripiprazole, 30 mg/day (reduced to 15 mg/day if needed for tolerabil...

OBJECTIVE To examine the efficacy of ziprasidone vs. placebo for the depressive mixed state in patients with bipolar disorder type II or major depressive disorder (MDD). METHODS 73 patients were randomized in a double-blinded, placebo-controlled study to ziprasidone (40-160 mg/d) or placebo for 6 weeks. They met DSM-IV criteria for a major depressive episode (MDE), while also meeting 2 or 3 (...

this study was aimed to evaluate the emotional intelligence (ei) of a group of patients with first episode psychosis in iran as compared with a healthy control group. a case-control design was used. ei was assessed using persian version of bar-on emotional quotient inventory (eq-i) administered on 25 patients with history of a single psychotic episode in the last two years, as well as 64 health...

Introduction Recognition of the essential role nature-based activities for general wellbeing is expanding. Currently, there limited evidence benefits green care those with severe and enduring mental illness, including psychosis. Objectives We aim to establish difficulties encountered during a 10-session programme 18-30 year olds who have experienced first episode psychosis (FEP) using mixed met...

BACKGROUND A 6-week double-blind, randomized, placebo-controlled trial was conducted to determine the efficacy of combined therapy with olanzapine and either valproate or lithium compared with valproate or lithium alone in treating acute manic or mixed bipolar episodes. METHODS The primary objective was to evaluate the efficacy of olanzapine (5-20 mg/d) vs placebo when added to ongoing mood-s...