Natural products isolated from plant sources are well known for their pharmacological potential in diversity of disease treatments such as inflammatory or cancer conditions. Mango (Mangifera indica L.) and Juglans regia are thought to be rich of functional phytochemicals. To elucidate the anticancer activity of Juglans regia (JR) and Mangifera indica L (MI) aqueous extract were investigated on ...

glaucoma is the second leading cause of irreversible blindness and a neurodegenerative disease with a complex pathogenesis. increasing evidence suggests that oxidative stress and mitochondrial dysfunction have crucial roles in most neurodegenerative diseases such as glaucoma. the conventional clinical treatment for glaucoma is lowering the intraocular pressure (iop). some patients have normal i...

mitochondria play an important role in energy production for the cell. the proper function of a myocardial cell largely depends on the functional capacity of the mitochondria.  therefore it is necessary to establish a novel and reliable method for a non-invasive assessment of mitochondrial function and metabolism in humans. although originally designed for evaluating myocardial perfusion, 99mtc...

-

Mitochondria play an important role in energy production for the cell. The proper function of a myocardial cell largely depends on the functional capacity of the mitochondria.  Therefore it is necessary to establish a novel and reliable method for a non-invasive assessment of mitochondrial function and metabolism in humans. Although originally designed for evaluating myocardial perfusion, 99mTc...

Background and Objective: Alzheimer’s disease (AD) is a neurodegenerative disorder which is associated with extracellular accumulation of amyloid beta (Aβ) plaques. AD is accompanied by mitochondrial dysfunction and energy metabolism reduction. Fibroblast growth factor 21 (FGF21) is an endogenous polypeptide which its beneficial effects have been demonstrated on mitochondrial function, energy m...

conclusions no association was found between tfam promoter methylation and mes. the present study suggests that the tfam promoter methylation is not associated with risk of mes. objectives the aim of study was to investigate the possible association between promoter methylation of mitochondrial transcription factor a (tfam) and mes. patients and methods dna was extracted from peripheral blood o...

The number of people with neurodegenerative disease continues to increase every year. A new perspective is needed overcome this disease. In review, researchers collected information about dysfunctional energy in diseases driven by mitochondria. Mitochondrial dysregulation can cause damage the neuron system. amount and interaction α-synuclein SAMM50 GABARAPL1 mitochondria one factors causing As ...

mitochondria are unique organelles with major role in cellular function, not only as a major site of atp production, but also by regulating energy expenditure, apoptosis signaling, and production of reactive oxygen species. they play a central role in determining the point-of-no-return for the apoptotic process. there is accumulating evidence supporting a direct link between mitochondria, oxida...