نتایج جستجو برای: mitochondrial biogenesis

تعداد نتایج: 150986  

2013
Anders Rodell Lene J. Rasmussen Linda H. Bergersen Keshav K. Singh Albert Gjedde

Stimulation of mitochondrial biogenesis during life-time challenges both eliminates disadvantageous properties and drives adaptive selection of advantageous phenotypic variations. Intermittent fission and fusion of mitochondria provide specific targets for health promotion by brief temporal stressors, interspersed with periods of recovery and biogenesis. For mitochondria, the mechanisms of sele...

Journal: :Molecular Biology of the Cell 2021

Ema19 is an integral endoplasmic reticulum (ER) protein with relevance for mitochondrial biogenesis. This yeast, representative of the TMEM97/sigma 2 receptor family, serves as quality control factor which supports degradation nonimported proteins. study again demonstrates important role ER in targeting.

Journal: :Kidney diseases 2023

<b><i>Background:</i></b> Podocytes are essential components of the glomerular filtration barrier and for proper function glomerulus. Podocyte injury under various stress conditions is primary pathogenesis key determinant focal segmental glomerulosclerosis (FSGS) with prominent clinical manifestations proteinuria or nephrotic syndrome. <b><i>Summary:</i&gt...

Journal: :Clinical and experimental pharmacology & physiology 2008
Glenn K McConell Glenn D Wadley

1. The present review discusses the potential role of nitric oxide (NO) in the: (i) regulation of skeletal muscle glucose uptake during exercise; and (ii) activation of mitochondrial biogenesis after exercise. 2. We have shown in humans that local infusion of an NO synthase inhibitor during exercise attenuates increases in skeletal muscle glucose uptake without affecting blood flow. Recent stud...

Journal: :Biochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics 1977

Journal: :Journal of Cellular and Molecular Medicine 2020

Journal: :Essays in Biochemistry 2010

Journal: :European review for medical and pharmacological sciences 2017
H Wang W-J Yan J-L Zhang F-Y Zhang C Gao Y-J Wang W Bond Law L Tao

OBJECTIVE Plasma adiponectin (APN) levels are decreased in diabetic patients. Dysfunctional mitochondrial biogenesis is involved in type 2 diabetes (T2DM) pathogenesis, by unclear mechanisms. The present study determined (1) whether myocardial mitochondrial biogenesis was impaired in cardiomyocytes exposed to a high glucose/high fat (HGHF) medium (a T2DM in vitro model), (2) the effects of APN ...

2017
Xin Zhan Wenjie Yu Reinaldo Franqui-Machin Melissa L. Bates Kalyan Nadiminti Huojun Cao Brad A. Amendt Yogesh Jethava Ivana Frech Fenghuang Zhan Guido Tricot

Many cancers, including multiple myeloma (MM), retain more cytosolic iron to promote tumor cell growth and drug resistance. Higher cytosolic iron promotes oxidative damage due to its interaction with reactive oxygen species generated by mitochondria. The variation of mitochondrial biogenesis in different stages of MM disease was evaluated using gene expression profiles in a large clinical datas...

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