Introduction Misoprostol is used for the medical management of miscarriage as it is more effective in the early stages of pregnancy. Letrozole has an anti-estrogen effect and is used for the pretreatment of miscarriage with misoprostol. Aim The aim of this study was compare the efficacy and safety of letrozole with placebo pretreatment in the medical management of first trimester missed misca...

Objectives To clarify pregnancy outcomes in patients with systemic sclerosis (SSc), lupus erythematosus (SLE) and Behcet’s disease (BD) using retrospective analysis. Methods The study group included 48 women SSc, 47 SLE 45 BD aged 20-40 years, the control - 15 age-matching healthy women. SSc pts’ mean age was 32,9 [28;37] 32,3 [29;36] pts‘ 31,3 [27;35] duration 6,3 [3;10], 9,8 [3;16] 6,0 [3;8] ...

OBJECTIVE Investigation of the possible role of leptin in early pregnancy failure. METHODS Leptin concentration was measured in maternal serum, coelomic fluid and amniotic fluid from 15 singleton pregnancies with live fetuses and 7 missed miscarriages at 7-10 weeks of gestation. RESULTS In the pregnancies with live fetuses, the median leptin concentration was significantly higher in coelomi...

BACKGROUND This study aims to assess the efficacy of a combination of mifepristone and misoprostol in the management of missed miscarriage and anembryonic pregnancy. METHODS Data of 220 consecutive women with miscarriage, undergoing medical evacuation of the uterus were collected prospectively at an early pregnancy assessment unit in a tertiary referral hospital. Each woman received a single ...

BACKGROUND Decidual vascular development is important for implantation. This study analysed decidual vascular adaptation to implantation in correlation with miscarriage in decidual secretory endometrium (DSE), decidua parietalis (DP) and decidua basalis (DB) of miscarriage patients and matched controls. METHODS Decidua was obtained during first trimester termination of pregnancy (controls) an...

Introduction: With the publication of four papers in late 2011, international cut-offs for definitions of non-viability in the first trimester of pregnancy were challenged. These definitions were inconsistent across different international guidelines. For example, a gestational sac with absent yolk sac or embryo and a mean diameter of ≥ 16 mm would be classified as a miscarriage in the USA, whe...