-Misonidazole (MISO) potentiates the action of cyclophosphamide (CY) and melphalan in the WHFIB culture-adapted fibrosarcoma, whether assayed by cell survival or tumour-growth delay. In the case of CY, MISO also inhibited recovery from potentially lethal drug damage. The optimum effect was seen when MISO was given 1 h before CY, though it was also effective when given 6 h before or 1 h after th...

Elderly people often suffer from taste disorder, with subsequent appetite loss. A reduction in umami-taste sensitivity is strongly related to appetite loss. Under these circumstances, how is umami taste considered and applied to foods for the elderly in Japan? In this study, we measured the concentration of L-glutamate (a typical umami amino acid) in 658 different miso soups served in 220 insti...

The purpose of this study was to compare the effects of Miso and sodium chloride (NaCl) on blood pressure in both sexes Dahl and SD rats. The systolic and diastolic blood pressures were measured at 2, 4, 8 and 12 weeks of treatment with a Miso diet including 2.3%NaCl or diets with 2.3% and 1.9% NaCl or normal diet (MF diet, Oriental Yeast Co) with 0.3% NaCl diet. The rats were autopsied after 1...

In this paper we consider MISO fractional systems with delays that are given by their transfer function. For a large class of such systems, we determine left coprime factorizations as well as associated Bézout factors, and guarantee the existence of right coprime factorizations.

Japanese soybean paste miso, which has been reported to prevent gastric and mammary cancer and chronic nephritis, was demonstrated by electron spin resonance spectrometry using 5,5'-dimethyl-1-pyrroline-N-oxide as a scavenger of free radicals. Fifty mg/ml of miso scavenged 100% of 1,1-diphenyl-2-picrylhydrazyl radicals (3.9 x 10(15) spins/ml); 45 mg/ml quenched 92% of hydroxyl radicals (7.9 x 1...

Abstract – A voltage-mode (VM), multi-input single-output (MISO) type multifunction biquad is proposed. It uses only one operational transresistance amplifier (OTRA) as the active element, while previously reported VM multifunction filters require more OTRAs. Proposed MISO type biquad configuration can realize all five different filter transfer functions. Theoretical results are verified with P...

We introduce MISO, the Mixed-Integer Surrogate Optimization framework. MISO aims at solving computationally expensive black-box optimization problems with mixed-integer variables. Although encountered in many applications, such as optimal reliability design or structural optimization, for example, where time consuming simulation codes have to be run in order to obtain an objective function valu...

PURPOSE 2-Nitro-alpha-[(2,2,2-trifluoroethoxy)methyl]-imidazole-1-ethanol (TF-MISO) was investigated as a potential noninvasive marker of tissue oxygen levels in tumors using (19)F magnetic resonance spectroscopy (MRS) and (19)F chemical shift imaging. EXPERIMENTAL DESIGNS In vitro data were obtained using high-performance liquid chromatography on tumor cells incubated under varying oxygen co...