DNA methylating agents such as N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) are potent carcinogens; their carcinogenic effect is mainly due to the effect of production of O6-methylguanine (O6 MeG) on DNA. O6 MeG is not only mutagenic but also toxic to the cell because Mer-/Mex- cells unable to remove O6 MeG are very sensitive to killing by MNNG. It has been proposed that repeated futile mismatch...

We present results for an identical setup as reported in Section 5.1, with the only difference being that the test functions have been sampled from a GP with rational quadratic kernel with length scale l = 0.1 and scale mixture α = 1.0. The kernel used in the GP surrogate model is not modified, i.e., an RBF kernel with length scale l = 0.1 is used. Thus, since different kind of kernel govern te...

Mismatch between bone marrow transplant (BMT) patient and donor for an amino acid polymorphism within the adhesion molecule CD31 has recently been reported to increase risk for the development of graft-versus-host disease (GVHD). We further examined this association in a larger series of 301 BMT patients (227 with grade III/IV GVHD and 74 with grade 0 GVHD) and their HLA-identical sibling donor...

Repair of mismatches in DNA in mammalian cells is mediated by a complex of proteins that are members of two highly conserved families of genes referred to as MutS and MutL homologues. Germline mutations in several members of these families, MSH2, MSH6, MLH1, and PMS2, but not MSH3, are responsible for hereditary non-polyposis colorectal cancer. To examine the role of MSH3, we generated a mouse ...

The Huntington's disease gene (HTT) CAG repeat mutation undergoes somatic expansion that correlates with pathogenesis. Modifiers of somatic expansion may therefore provide routes for therapies targeting the underlying mutation, an approach that is likely applicable to other trinucleotide repeat diseases. Huntington's disease Hdh(Q111) mice exhibit higher levels of somatic HTT CAG expansion on a...

[1] A mismatch of elastic properties across a fault induces normal stress changes during spatially nonuniform in-plane slip. Recently, Rudnicki and Rice showed that similar effects follow from a mismatch of poroelastic properties (e.g., permeability) within fluid-saturated fringes of damaged material along the fault walls; in this case, it is pore pressure on the slip plane and hence effective ...

We contrast the spatial mismatch hypothesis with what we term the racial mismatch hypothesis - that the problem is not a lack of jobs, per se, where blacks live, but a lack of jobs where blacks live into which blacks are hired. We first report new evidence on the spatial mismatch hypothesis, using data from Census Long-Form respondents. We construct direct measures of the presence of jobs in de...

The paper presents smallholder farmers' perceptions on attributes of bread wheat varietiesbased on primary data collected from 524 households in four major wheat growing areas ofEthiopia. The results indicated high value of attainment indices for improved varieties comparedto landraces, which shows how the demanded attributes are embodied more in improved ones.Grain yield and yellow and stem ru...

BACKGROUND The study was designed to evaluate the effects of moderate prosthesis-patient mismatch (defined as 0.65 cm(2)/m(2) <indexed effective orifice area ≤ 0.85 cm(2)/m(2)) on midterm outcomes after isolated aortic valve replacement with a 17-mm St. Jude Medical Regent valve in a large series of patients, and to determine if these effects are influenced by patient confounding variables. M...