نتایج جستجو برای: mird
تعداد نتایج: 217 فیلتر نتایج به سال:
The development of novel, systemically administered radionuclide therapies (such as radioimmunotherapy) relies on the ability to predict dose-limiting toxicity to normal tissue. Where the kidney is the principal route of excretion of the radionuclide preparation and/or breakdown of products, nephrotoxicity may be the dose-limiting factor. Until recently, conventional (MIRD) dosimetry assumed th...
BACKGROUND AND PURPOSE We assessed the contribution of antibody internalization in the efficacy and toxicity of intraperitoneal α-radioimmunotherapy (RIT) of small volume carcinomatosis using (212)Pb-labeled monoclonal antibodies (mAbs) that target HER2 (internalizing) or CEA (non-internalizing) receptors. MATERIALS AND METHODS Athymic nude mice bearing 2-3 mm intraperitoneal tumor xenografts...
BACKGROUND The aim of the study is to assess accuracy of activity quantification of 177Lu studies performed according to recommendations provided by the committee on Medical Internal Radiation Dose (MIRD) pamphlets 23 and 26. The performances of two scatter correction and three segmentation methods were compared. Additionally, the accuracy of tomographic and planar methods for determination of ...
Introduction: Existing phantoms have been constructed based on Caucasian, non-Caucasian and race-specific datasets. According to previous studies made efforts to present Korean- specific phantoms and Chinese female phantom based on CVH dataset due to compare the resulting internal dosimetry with the Caucasian based data showed possible racial difference in human anatomy between ...
چکیده زمینه و هدف: رادیوایزوتوپ 131 i در درمان پرکاری و سرطان تیرویید به طور گسترده استفاده می شود. از این رو محاسبه دقیق دز جذبی در تیرویید و دیگر اعضای بدن حائز اهمیت است. مواد و روش ها: در این پژوهش، با توجه به روش mird و با استفاده از کد محاسباتی mcnp ، دُز جذبی ناشی از چشمه رادیواکتیو 131 i برای تیرویید با جرم و اندازه معین محاسبه شده است. یافته ها: نتایج حاصل از دو هندسه در نظر گرفته...
UNLABELLED The isotopes 55Co and 57Co have been evaluated for PET and SPECT imaging in several clinical brain studies. For clinical application of cobalt, it is important to know the delivered radiation dose. The biodistribution of 55Co in both rat and humans after intravenous (bolus)-administration was studied. Based on pharmacokinetic data, radiation dose calculations according to the MIRD sy...
Introduction: Radioactive materials deliver internal radiation dose to patients in nuclear medicine. Manual internal radiation dose assessment is a complicated method. Introduction of a simple dose calculation software is the main goal of the present study. Methods: Using the best current data in internal dose calculation (S-Factors) recommended by ICRP and by cons...
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