MicroRNAs are short single‑stranded non‑coding RNA molecules that function as regulators of tumor progression, including regulation of glioblastoma multiforme, which is a World Health Organization grade Ⅳ glioma. Based on the results of a microRNA microarray, which included 198 patients with glioma from the Chinese Glioma Genome Atlas data set, it was observed that microRNA‑206 (miR‑206) was do...

MicroRNA-206 (miR-206), the homolog of which in mice is termed miR-206-3p, is a muscle-specific miRNA known to be important in the development of skeletal muscle, and is involved in smooth muscle innervation of the airway through the post‑transcriptional suppression of brain‑derived neurotrophic factor (Bdnf). miR‑206‑3p is also expressed at significant levels in adult and embryonic skin; howev...

MicroRNAs are endogenous short chain nucleotide RNAs that regulate gene function by direct binding of target mRNAs. In this study, we investigated the effects of microRNA-206 (miR-206) on the development of gastric cancer. miR-206 was first confirmed to be downregulated in gastric cancer specimens. Conversely, upregulation of c-Met was confirmed in tissue samples of human gastric cancer, with i...

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related mortality worldwide. Angiogenesis is the major hallmark in NSCLC. So, further elucidation of molecular mechanisms underlying the angiogenesis of NSCLC is urgently needed. Here, we found that microRNA-206 (miR-206) decreased the angiogenic ability in NSCLC via inhibiting the 14-3-3ζ/STAT3/HIF-1α/VEGF pathway. Briefly, 14-3...

Neuropathic pain (NP), chronic pain resulted from dysfunction or diseases of the somatosensory nervous system, is a major challenge to currently available clinical therapy of peripheral nerve injury. Although there are significant improvements in drug and surgical therapy, the efficiency of the therapeutic approach for NP is low. And the molecular mechanisms of NP maintenance are still not clea...

MicroRNAs (miRNAs) play a critical role in drug resistance and epithelial-mesenchymal transition (EMT). The aims of this study were to explore the potential role of miR-206 in governing cisplatin resistance and EMT in lung cancer cells. We found that both lung adenocarcinoma A549 cisplatin-resistant cells (A549/DDP) and H1299 cisplatin-resistant cells (H1299/DDP) acquired mesenchymal features a...

miR-206 plays an important role in regulating the growth of multiple cancer cells. Cyclin-dependent kinase 9 (CDK9) stimulates the production of abundant prosurvival proteins, leading to impaired apoptosis of cancer cells. However, it is unknown whether CDK9 is involved in the miR-206-mediated growth suppression of hepatocellular carcinoma (HCC) cells. In this study, we found that the expressio...

MicroRNAs (miRNAs) constitute of a class small non-coding RNAs that are involved in post-transcriptional gene regulation and have important regulatory roles in many fundamental biological processes. A small number of miRNAs predominantly expressed in muscle tissue have been found to play critical role in myogenesis, muscle growth, cardiac function and muscle hypertrophy. In the present study, t...

MicroRNAs (miRNAs) constitute of a class small non-coding RNAs that are involved in post-transcriptional gene regulation and have important regulatory roles in many fundamental biological processes. A small number of miRNAs predominantly expressed in muscle tissue have been found to play critical role in myogenesis, muscle growth, cardiac function and muscle hypertrophy. In the present study, t...

MicroRNAs (miRNAs) constitute of a class small non-coding RNAs that are involved in post-transcriptional gene regulation and have important regulatory roles in many fundamental biological processes. A small number of miRNAs predominantly expressed in muscle tissue have been found to play critical role in myogenesis, muscle growth, cardiac function and muscle hypertrophy. In the present study, t...