Abstract Objective Clinical manifestation of the inflammatory process in its relation to biochemical markers (total cysteine [Cys], cysteine-glycine [CysGly], glutathione [GSH], glutamate-cysteine [Glu-Cys], homocysteine [Hcy], ratio reduced oxidized [GSH/GSSG], [CySH/CySS], malondialdehyde-oxidized low-density lipoproteins [MDA-oxLDL]) has been studied patients with coronavirus disease 2019 (C...

glutathione (gsh) is one of the most important antioxidants that plays an essential role in detoxification of reactive oxygen species (ros) which oxidizes to glutathione disulfide (gssg). paraquat (pq), awidely used herbicide, causes pulmonary injury with the productionof ros. excessive ros accumulation as a consequence of pq exposure are frequently targeted by gsh thereby oxidative stress lead...

introduction: the fate of xenobiotics that is present, increasing day by day. the increasing fates altered or inhibit the metabolic activities like detoxification and biotransformation. methods: the present study highlights this slow biotransformation and detoxification on the basis of specific enzymes which have a say in assessment of mercuric chloride toxicity and modulation by panax ginseng ...

Hypothermia to mitigate ischemic brain tissue damage has a history of about six decades. Both in clinical and experimental studies of hypothermia, two principal arbitrary patterns of core temperature lowering have been defined: mild (32-35 degrees C) and moderate hypothermia (30-33 degrees C). The neuroprotective effectiveness of postischemic hypothermia is typically viewed with skepticism beca...

Targeted temperature management was adopted as part of the treatment of unconscious survivors of out-ofhospital cardiac arrest following the publication of two landmark studies [1,2] which concluded that mild induced hypothermia (32°C to 34°C) improved survival and neurological outcome, substantiating the neuroprotective effect of mild hypothermia described in experimental animal data [3]. Subs...

The effective delivery of protein therapeutics remains a major challenge. Here, the novel nanoplatforms with bovine serum albumin (BSA)-coated, Dnase-1-loaded MnOx nanoflowers are developed (denominated MD@BSA). These MD@BSA present highly efficient loading and Dnase-I into tumor cells. Under glutathione (GSH) overexpression environment, is degradable, resulting in Dnase-1 Mn2+ release for comb...

This study was performed on 17 hyperthyroid patients and 15 healthy controls. The patients were under propylthiouracil (PTU) therapy at a dosage of 3 x 100 mg/day for one month. Blood samples, taken at the beginning and on the 30th day of therapy, were analyzed for hormonal parameters (T3, T4, TSH), lipid peroxidation endproduct [thiobarbituric acid reactive substances (TBARS)] and antioxidant ...

Abstract Nanodynamic therapy (NDT) based on reactive oxygen species (ROS) production has been envisioned as an effective cancer treatment. However, the efficacy is limited by hypoxia, insufficient hydrogen peroxide conversion, and high glutathione (GSH) levels in tumor microenvironment (TME). To solve these issues, we proposed designed a biocompatible, resistant Cu-modified Ti 3 C 2 nanocomposi...

Mild hypothermia (32-34°C) is a promising new therapy for patients resuscitated from cardiac arrest. Animal studies suggest that early and fast cooling is crucial. Inducing mild hypothermia immediately after successful restoration of spontaneous circulation (ROSC) out-ofhospital remains a challenge. Therefore, a novel coolingblanket (EMCOOLSpad®), independent of any energy source during use, wa...

Hypoxia in the tumor microenvironment (TME) greatly limits tumor-killing therapeutic efficacy of sonodynamic therapy (SDT); this phenomenon is further exacerbated by increased glutathione (GSH) levels cancer cells. Simultaneously, starvation increasingly recognized nowadays as a promising clinical translation, but glucose oxidase (GOx)-based also limited lack oxygen tumor. Glycer-aldehyde-3-pho...