For culverts installed in soft soil, the rigid composite pile foundation is used for soil treatment, and stresses around are complicated. Centrifuge experiments numerical simulations conducted to investigate vertical earth pressures settlement over a slab culvert under high backfill foundations treated with piles. The influences of lateral length spacing on at top analysed, they have significan...

To analyze the seismic response characteristics of unequal-span subway station structures in saturated sites, a three-dimensional numerical model an structure is established, based on finite element analysis software MIDAS-GTS. The elastic modulus, cohesion, Poisson’s ratio, and friction angle are selected as sensitivity parameters. Moreover, combined with two-phase medium dynamic method, ortho...

The dynamic responses of pile–liquefied composite soils are complex, and the bearing capacities single piles or pile groups in liquefiable remain unclear. For friction piles, resistance determines vertical capacity pile. In a pile–soil system, it is very important to study changes during vibration. Based on shaking table test, this investigated foundation–liquefied soil system under simulated h...

With the increasing prevalence of deep foundation pit projects in modern urban construction, deformation control associated support structures is crucial to ensuring construction safety. Despite growing importance this issue, research on excavation soft soil areas near sea limited. This study investigates characteristics and impact a geometrically complex project Taizhou, utilizing both long-te...

Introduction: GTS-21 ((3E)-3-[(2,4-dimethoxyphenyl)methylene]-3,4,5,6tetrahydro-2,3’-bipyridine), a partial α7 nicotinic acetylcholine receptor agonist drug, has recently been shown to improve cognition in schizophrenia and Alzheimer’s disease. One of its two major demethylated metabolites, 4-OH-GTS-21, has been suggested to contribute to its therapeutic effects. Methods: We labeled GTS-21 in t...

To investigate the regulatory system in mitochondrial biogenesis involving crosstalk between the mitochondria and nucleus, we found a factor named MIDAS (mitochondrial DNA absence sensitive factor) whose expression was enhanced by the absence of mitochondrial DNA (mtDNA). In patients with mitochondrial diseases, MIDAS expression was increased only in dysfunctional muscle fibers. A majority of M...

The formation of species in the absence of geographic barriers (i.e. sympatric speciation) remains one of the most controversial topics in evolutionary biology. While theoretical models have shown that this most extreme case of primary divergence-with-gene-flow is possible, only a handful of accepted empirical examples exist. And even for the most convincing examples uncertainties remain; compl...