The creatine/phosphocreatine system, regulated by creatine kinase, plays an important role in maintaining energy balance in the brain. Energy metabolism and the function of creatine kinase are known to be affected in Alzheimer diseased brain and in cells exposed to the beta-amyloid peptide. We used infrared microspectroscopy to examine hippocampal, cortical, and caudal tissue from 21-89-week-ol...

The current paper describes rather new and straightforward non-invasive mid infrared spectroscopic techniques for the position sensitive identification of sample components. These techniques include mid infrared (MIR) microspectroscopy, mapping as well as imaging approaches e.g. in transmission, reflection-absorption, or attenuated total reflection mode. The basic principles of the different in...

miconazole is an imidazole antifungal agent, commonly applied topically to the skin or mucous membranes. the aim of this study was to examine the alternative method for gaining mechanism or the bimolecular changes caused by the possible teratogenic effects of miconazole on mice fetus brain tissue using ftir-microspectroscopy. the mice were injected with miconazole (60 mg/kg) on gestation day 9....

PARTICLES: HRTEM AND RAMAN MICROSPECTROSCOPY Frans J. M. Rietmeijer, Janet Borg and A. Rotundi; Department of Earth and Planetary Sciences, MSC03-2040, 1-University of New Mexico, Albuquerque, NM 87131-0001, USA; Institut d'Astrophysique Spatiale, Bâtiment 121, Campus 91405 Orsay Cedex, France; Ist. di Matematica, Fisica e Applicazioni, Università di Napoli "Parthenope", Via A. De Gasperi 5, 80...

Acetaminophen is a widely prescribed drug used to relieve pain and fever; however, it is a leading cause of drug-induced liver injury and a burden on public healthcare. In this study, hepatotoxicity in mice post oral dosing of acetaminophen was investigated using liver and sera samples with Fourier Transform Infrared microspectroscopy. The infrared spectra of acetaminophen treated livers in BAL...

Vibrational spectroscopy analyses vibrations within a molecule and can be used to characterise a molecular structure. Raman spectroscopy is one of the vibrational spectroscopic techniques, in which incident radiation is used to induce vibrations in the molecules of a sample, and the scattered radiation may be used to characterise the sample in a rapid and non-destructive manner. Infrared (IR) s...

Infrared (IR) microspectroscopy was used to detect disease-associated molecular changes spatially resolved in cryosections of scrapie-infected tissue of the CNS. The results show that IR spectra can be used for the discrimination between normal and 263K scrapie-infected hamster nervous tissue not only in the terminal stage of the disease but also in early clinical and even in the preclinical st...