Brain arteriovenous malformations (AVMs) are abnormal vessels that prone to rupture, causing life-threatening intracerebral hemorrhage (ICH). Understanding the molecular basis of pathogenesis, timely diagnosis, and treatment brain AVMs some urgent problems in neurosurgery. MicroRNAs (miRNAs) small endogenous RNAs regulate gene-expression posttranscriptionally. MiRNAs involved almost all biologi...

Sarcoma is a rare cancer with several subtypes; therefore, our understanding of the pathogenesis sarcoma limited, and designing effective treatments difficult. Circulating microRNAs (miRNAs), including exosomal miRNAs, have attracted attention as biomarkers in cancer. However, roles miRNAs exosomes remain unclear. The present analysis tissue serum miRNA expression osteosarcoma, Ewing's dediffer...

cardiovascular disease has become the main factor of death and birth defects in the world. there are some therapeutic structures and drugs for curative and palliative therapy of the disease, but to the aim of accessing reliable therapy or to postpone onset of disease, especially for individuals with heritable coronary artery disease in their pedigree genetic engineering technologies are making ...

Diffuse large B-cell lymphoma is the most common type of non-Hodgkin lymphoma. MicroRNAs (miRNAs) are endogenous small RNA, which can regulate gene expression at the post-transcriptional level. MiRNA profiling has shown a great potential as novel diagnostic and prognostic biomarkers. The present study was performed at the Nemazee Teaching Hospital (Shiraz, Iran) from 2011 to 2013.The aim of thi...

Wound healing is a complex process involving inflammation, cellular proliferation, and matrix remodeling. However, skin's regenerative capacity varies across species, adult mammals, including humans, have limited ability to fully regenerate tissue. Scar formation common outcome of wound healing, impacting quality life. MicroRNAs (miRNAs) are key regulators in influencing cell angiogenesis, Dysr...

MicroRNAs (miRNAs) are small preserved non-coding RNA molecules that regulate gene expression post-transcriptionally by targeting the 3' UTR of mRNAs for translational repression or degradation. The rising evidence has established the significant role of miRNAs within the regulation of immune system and the prevention of autoimmunity. MiR-146a has obtained an importance as a modulator of differ...

MicroRNAs (miRNAs) are endogenous non-coding RNAs that have significant roles in biological processes such as glucose homoeostasis. MiRNAs fine-tune target genes expression via sequence-specific binding of their seed sequence to the untranslated region of mRNAs and degrade target mRNAs. MicroRNAs in islet β-cells regulate β-cell differentiation, proliferation, insulin transcription and glucose-...

in the retinoblastoma research, it is of great interest to identify molecular markers associated with the genetics of tumorigenesis. micrornas (mirnas) are small non-coding rna molecules that play a regulatory role in many crucial cellular pathways such as differentiation, cell cycle progression, and apoptosis. a body of evidences showed dysregulation of mirnas in tumor biology and many disease...

results researchers have reported that mirnas can repress the expression of important cancer-related genes and might be helpful in the diagnosis and treatment of cancer. during the past two decades, numerous studies have shown that mirnas play an essential role in inhibiting hcc via several different pathways. deregulated mirnas may contribute to carcinogenesis, indicating that mirnas can act a...

BACKGROUND Application of genomics and Next Generation sequencing has led to the identification of new class of cellular functional molecules, namely, small RNAs. Of the several classes of ncRNAs (non-coding RNA), microRNAs have been demonstrated to exert determinative influence on various cellular processes. It is becoming abundantly clear that host/vector/pathogen encoded microRNAs impact eve...