background: genome instability is a main cause of chromosomal alterations in both somatic and germ cells when exposed to environmental, physical and chemical genotoxicants. germ cells especially spermatozoa are more vulnerable to suffering from dna damaging agents during spermatogenesis and also more potent in transmitting genome instability to next generation. methods: to investigate the effec...

background: mannitol is present in the ethyol ® (the trade name of amifostine) as an excipient. the mechanism of radioprotection of amifostine is radical scavenging. since mannitol is another known radical scavenger, we studied the probable additive or synergistic effect of mannitol on the effect of amifostine. material and methods: mice were irradiated with co-60 γ -ray in the presence 400mg/k...

To the Editor: I read the research findings of Basu et al. (1) with great interest. However, there are some points which should be discussed. The authors showed that the level of lymphocytes with micronuclei in control (unexposed) persons was extremely low (1.66%). For example, in some European nations it is between 7% and 18% (2-7), and the least is in Turkish subjects—2.8% (8). According to t...

To the Editor: I read the research findings of Basu et al. (1) with great interest. However, there are some points which should be discussed. The authors showed that the level of lymphocytes with micronuclei in control (unexposed) persons was extremely low (1.66%). For example, in some European nations it is between 7% and 18% (2-7), and the least is in Turkish subjects—2.8% (8). According to t...

Unrepaired or misrepaired radiation damage in mammalian chromosomes can result in micronucleus formation at the first cell division. This represents loss of genomic information which may cause cell death. To improve our understanding of the mechanism of radiation-induced micronucleus formation, we characterized micronucleus ultrastructure and identified the origin of micronucleus DNA. Immunoflu...

Diabetes Mellitus type 2 (DM2) is associated with increased cancer risk. Instability of the genetic material plays a key role in the aetiology of human cancer. This study aimed to analyse genomic instability with the micronucleus cytome assay in exfoliated buccal cells depending on glycated haemoglobin (HbA1c) levels and medication in 146 female DM2 patients. The occurrence of micronuclei was s...