This paper describes formulation considerations and in vitro evaluation of an oleic acid-based polyelectrolytic polymer-containing microemulsion drug delivery system designed for intranasal administration of a hydrophobic model drug Olanzapine. Drug-loaded microemulsions were successfully prepared by a water titration method. The microemulsion containing 4% oleic acid, 30% surfactant mixture of...

We predict, qualitatively, the structural transitions in microemulsion systems induced by nonionic polymers, by virtue of their ability to associate with the surfactant assemblies. The predictions are made possible by linking (a) theoretical calculations of the domains of existence of oil-in-water (O/W) and water-in-oil (W/O) droplet microemulsions with (b) the experimental observation that on ...

an anionic fe(ii) complex, (bmim)4[fe(cn)6] (where bmim is 1-butyl-3-methylimidazolium), was synthesized in ionic liquid [bmim][pf6] under reflux condition. the complex was characterized by elemental analysis and spectroscopic methods. the magnetite (fe3o4) nanoparticles were prepared by the hydrothermal and solvothermal (in ionic liquid [bmim][pf6]) methods from (bmim)4[fe(cn)6] as a precursor...

In the present work glipizide based microemulsion was developed and its usefulness as topical drug carrier system for the non-insulin dependent diabetes mellitus (NIDDM) was investigated. Microemulsion was prepared by water titration method using oleic acid as oil phase, tween-80 as surfactant and propylene glycol as co-surfactant. Menthol as a permeation enhancer was added to a final drug-load...

BACKGROUND A microemulsion is an effective formulation for improving the oral bioavailability of poorly soluble drugs. In this paper, a water-in-oil (w/o) microemulsion was investigated as a system for enhancing the oral bioavailability of Biopharmaceutic Classification System (BCS) III drugs. METHODS The microemulsion formulation was optimized using a pseudoternary phase diagram, comprising ...

ABSTRACT The new PSP pincer ligand 4,6-bis(diphenylphosphinomethyl)dibenzothiophene (PSPPh) was prepared in 89 % yield. With this ligand, a solvothermal synthesis of a Cr complex of the type [Cr(κ3P,S,P-PSP)(CO)3] is described. The X-ray structure of this compound is presented. We demonstrate that the solvothermal synthesis technique provides a powerful, simple, and practical synthetic method r...

objective(s): according to the unique properties of magnetic nanoparticles, nickel metal-organic frameworks (mof) was synthesized successfully by ultrasound irradiation. metal-organic frameworks (mofs) are organic–inorganic hybrid extended networks that are constructed via covalent linkages between metal ions/metal clusters and organic ligands called a linker. materials and methods: the nanopar...

The objective of the present investigation was to develop and evaluate microemulsion based gel for the vaginal delivery of Sertaconazole. The solubility of Sertaconazole in various oils, surfactants and co-surfactants were checked to identify components of the microemulsion. The ternary diagrams were plotted to identify the area of microemulsion existence. Various gelling agents were evaluated ...

A new electrochemical method to synthesize mesoporous nanowires of alloys has been developed. Electrochemical deposition in ionic liquid-in-water (IL/W) microemulsion has been successful to grow mesoporous CoPt nanowires in the interior of polycarbonate membranes. The viscosity of the medium was high, but it did not avoid the entrance of the microemulsion in the interior of the membrane's chann...

Constructing hierarchical and ultrathin-structured metal sulfides is beneficial for achieving high-efficiency hydrogen evolution catalysts. Herein, ZnIn2S4 (ZIS) hollow nanoflowers (HNFs) composed of ultrathin nanosheets are creatively synthesized via a facile trisodium citrate-mediated stirring-assisted solvothermal method. Experimental results reveal that the synergy effect ethanol, citrate, ...