Departments of Pathology, Urology, and Internal Medicine, University of Michigan, Ann Arbor, Michigan; Department of Cell Biology, Baylor College of Medicine, Houston, Texas; Departments of Oncology and Urology, The Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts; and Na...

*Department of Radiation Medicine, Oregon Health & Science University, Portland, Oregon; yDepartment of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama; zMD Anderson Cancer Center, Houston, TX; xDepartment of Radiation Oncology, University of Michigan, Ann Arbor, Michigan; jjDepartment of Radiation Oncology, Princess Margaret Cancer Center, Toronto, Ontario, Canada;...

There are still a limited number of primary interventions for prevention breast cancer. For women at high risk developing cancer, the most effective intervention is prophylactic mastectomy. This drastic surgical procedure in which mammary epithelial cells that can give rise to cancer completely removed along with surrounding tissue. The goal this protocol demonstrate feasibility minimally invas...

Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, New York; School of Medicine and Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania; Royal Marsden Hospital, Surrey, Sutton, United Kingdom; Loyola University Medical Center, Maywood, Illinois; American Cancer Society, Atlanta, Georgia; St. Jude Children’s Research Hospital, Memphis, Tennessee; Unive...

1 Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan, United States of America, 2 NICTA Victoria Research Laboratory, University of Melbourne, Melbourne, Victoria, Australia, 3 Computational Cancer Biology, Netherlands Cancer Institute, Amsterdam, The Netherlands, 4 VIB Department of Plant Systems Biology, Ghent University, Ghent,...

1 Department of Otolaryngology, University of Michigan, 1904TC/1500 E. Medical Center Drive, Ann Arbor, Michigan 48109 2 The Johns Hopkins Oncology Center, Medical Oncology, Baltimore, Maryland 3 M.D. Anderson Cancer Center, Houston, Texas 4 University of Chicago Medical Center, Chicago, Illinois 5 National Institute of Health, National Cancer Institute, Rockville, Maryland 6 Memorial Sloan Ket...

Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, New York; School of Medicine and Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania; Royal Marsden Hospital, Surrey, Sutton, United Kingdom; Loyola University Medical Center, Maywood, Illinois; American Cancer Society, Atlanta, Georgia; St. Jude Children’s Research Hospital, Memphis, Tennessee; Unive...

Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA Department of Computational Medicine & Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA Biostatistics and Bioinformatic...

chronic myeloid leukemia (cml) is a myeloproliferative disease of the hematopoietic stem cells, characterized by the presence of the philadelphia (ph) chromosome. although imatinib inhibits the bcr-abl kinase activity, clinical experiences confirm that imatinib may not target cml stem cells in vivo. the identification of signaling pathways responsible for the self-renewal properties of leukemic...