Antinuclear antibodies (ANA) were found in 54 (7.0%) out of 767 treated hypertensive patients compared with 59 (2.4%) out of 2470 healthy controls. Inclusion of a non-practolol beta-blocker in the treatment regimen did not significantly affect the incidence of ANA. ANA was found in significantly more patients being treated with methyldopa (13.0%) than patients receiving other hypotensive agents...

A spectrophotometric method was developed for the determination of methyldopa. The is based on oxidative coupling reactions with 4,2-dinitrophenylhydrazine as a reagent and in presence oxidizing agent potassium periodate acidic medium. product exhibits maximum absorption at 428 nm, Beer's law-subjective concentration range (1-30) µg/ml, molar absorbance 6589,908 liters. mol-1.cm-1. relative sta...

Methyldopa has been shown to be an effective hypotensive agent both in animals and in man (Oates et al., 1960), and valuable in the treatment of hypertension, particularly in the management of mild or moderately severe cases (Dollery and Harington, 1962; Bayliss and Harvey-Smith, 1962). Pharmacological activity resides entirely in the L-isomer (Gillespie et al., 1962). The mechanism of the anti...

AIMS This study dealt with the effect of chronic ethanol administration on hemodynamic responses elicited by alpha(2)-adrenergic (alpha-methyldopa) or I(1)-imidazoline (rilmenidine) receptor activation in telemetered female rats. MAIN METHODS The effects of alpha-methyldopa or rilmenidine on blood pressure (BP), heart rate (HR) and their variability were investigated in rats that received liq...

A modification of the Polybrene technique for red blood cell antibody characterization has been employed to differentiate the panhemagglutinins arising during methyldopa administration from those accompanying other disease states. Dissociation characteristics of methyldopa-associated antigen-antibody complexes were determined by temperature gradient dissociation technique. Data obtained by this...

Studies of catecholamine concentrations in defined nuclei from the anterior hypothalamic-preoptic regions and the medulla oblongata, known to contribute to cardiovascular control, were measured following acute or chronic methyldopa administration. These studies indicated that methyldopa was enzymatically converted to methyldopamine and methylnorepinephrine, and in some areas to methylepinephrin...