Abstract: Systematic studies on the substituent effect in para substituted Fe(CO)4–pyridine complexes have been studied on the basis of DFT quantum-chemical calculations. The following substituents were taken into consideration: NO2, CN, CHO, F, H, CH3, and OH. Additionally, the Fe–N and Fe–C bonds were characterized on the basis of Atoms in Molecules topological analysis of electron density. I...

First, Schiff base iminopyridine ligands has been prepared by the condensation between primaryamines, different substituted anilines and active carbonyl group of pyridine carboxaldehyde, thenthe complexes [diiodo (3-ethylphenyl) pyridine-2-yl methylene amine] mercury(II), complex a,[dibromo (2,5-dimethylphenyl) pyridine-2-yl methylene amine] mercury(II) complex b, and[dinitrato bis-(2,6-dimethy...

nicotine-based ionic liquid has been used as a green catalyst for pyridine-catalyzed huisgen reaction. it promoted addition of dimethylacetylenedicarboxylate to aldehydes or n-tosyl imines leading to efficient synthesis of 2-benzoylfumarates and 1-azadienes respectively under pyridine free odorless ionic liquid conditions. the improved results were obtained in terms of enhanced yields, with min...

dacarbazine is an antitumor prodrug which is used for the treatment of malignant metastatic melanoma and hodgkin’s disease. it requires initial activation in liver through an n-demethylationreaction. the active metabolite prevents the progress of disease via alkylation of guanine bases in dna strands. in order to investigate the importance of imidazole ring and its dynamictautomerization in ant...

Z. Naturforsch. 54 b, 8-12 (1999); received September 1, 1998 Silylamines, Silylamides, Crystal Structure Lithiation of tris(methylamino)wt'f/7v/silane using an excess of n -butyllithium affords the cor­ responding trifunctional lithium amide in high yield. The compound crystallizes from tetrahydrofuran as a dimer with six donor molecules: {[MeSi(NMeLi)3]2(thf)6}. The cluster is a cage structur...

From the leaves of Sarcococca coriacea two new steroidal alkaloids, epoxynepapakistamine-A [(20S)-20-(N-methylamino)-3beta-(tigloylamino)-5alpha-pregna-16alpha,17alpha-epoxy-2beta,4beta-di-O-acetate] (1), and epoxysarcovagenine-D [(20S)-20-(N-methylamino)-3beta-(tigloylamino)-5alpha-pregna-2-en-16alpha,17alpha-epoxy-4-one] (2), and two known compounds funtumafrine C [(20S)-20-(N,N-dimethylamino...

In this work, some new heterocyclic systems 10-(aryl)-3-alkyl-6-methyl-6,8-dihydroimidazo[4′,5′:3,4]benzo[1,2-e][1, 4]diazepin-7(3H)-ones were obtained from the reaction of o-N-methylamino-ketone benzimidazoles with glycine in good yields. The structures compounds confirmed by elemental analyses, IR, mass, and NMR spectra. Also, their interactions studied vitro on recombinant benzodiazepine rec...

This paper reviews the metabolism of new designer drugs of abuse that have emerged on the black market during the last years and is an update of a review published in 2005. The presented review contains data concerning the so-called 2C compounds (phenethylamine type) such as 4-bromo-2,5-dimethoxy-beta-phenethylamine (2C-B), 4-iodo-2,5-dimethoxy-beta-phenethylamine (2C-I), 2,5-dimethoxy-4-methyl...