OBJECTIVE To identify anti-hypoxia ingredients extracted from Portulaca oleracea and to find out the possible mechanism of its anti-hypoxia actions. METHODS Seventy mice were randomly divided into seven groups which were untreated (normal saline), ginsenosides-treated, polysaccharide-treated, acidic components-treated, basic components-treated, alkaloids-treated and flavones-treated groups, a...

eight salvia l. species including s. spinosa l., s. reuterana boiss., s. macrosiphon boiss., s. syriaca l., s. nemorosa l., s. virgata jacq., s. sharifii rech. f. & esfand. and s. mirzayanii rech. f. & esfand. were studied for flavonoid compounds. these constituents were analyzed using two-dimensional maps on silica gel 60f thin layer chromatography. the flavonoid compounds of each spec...

Citrus polymethoxylated flavones (PMFs) have recently been shown to suppress inflammation in peripheral tissues. In the present study, we investigated the effects of 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF), one of the PMFs, on inflammation in the brain in vivo using mice injected intrahippocampally with lipopolysaccharide (LPS). We demonstrated that subcutaneously injected HMF suppressed: (1)...

The oxidative cyclisation reactions of 2’-hydroxychalcones to corresponding aurones and flavones are discussed. While Hg2+, Cu2+ and Tl3+-mediated oxidative cyclisation of 2’-hydroxychalcones selectively give aurones, I2, Se4+, In3+, Cu+ and Fe3+-mediated reactions preferable give flavones. The general mechanisms of these oxidative cyclisation reactions are proposed.

Polymethoxylated flavonoids occur in a number of plant families, including the Lamiaceae. To date, the metabolic pathways giving rise to the diversity of these compounds have not been studied. Analysis of our expressed sequence tag database for four sweet basil (Ocimum basilicum) lines afforded identification of candidate flavonoid O-methyltransferase genes. Recombinant proteins displayed disti...

High performance liquid chromatography (HPLC) with diode array detection (DAD) and electrospray ionization tandem mass spectrometry (ESI/MS/MS) was used to analyze the main components in the methanol extract of Fructus Aurantii (FA) and the metabolites in rat biological samples after oral administration of the methanol extract of FA. There were 31 constituents identified in the extract of FA in...

Four Chinese pomegranate (Punica granatum L.) cultivars were analyzed for their individual flavonols and flavones (in fruit peel extracts) using High Performance Liquid Chromatography (HPLC), with changes in flavonols and flavones as occurring during fruit development. The results revealed the presence of kaempferol, quercetin, myricetin, luteolin, and apigenin in all the four cultivars. In add...

Flavones (from the Latin flavus, which means “yellow”) are a kind of flavonoid with backbone 2-phenylchromen-4-one. Flavones, one most important classes plant secondary metabolites, well-known for their anti-cancer, anti-inflammatory, anti-microbial, antioxidant, anti-osteoporatic, anti-diabetic, anti-estrogenic, anti-allergic, and metal chelating properties. These family compounds have been in...