نتایج جستجو برای: methamphetamine psychosis
تعداد نتایج: 24061 فیلتر نتایج به سال:
17β-estradiol treatment has shown benefit against schizophrenia symptoms, however long-term use may be associated with negative side-effects. Selective estrogen receptor modulators, such as raloxifene and tamoxifen, have been proposed as suitable alternatives to 17β-estradiol. An isomer of 17β-estradiol, 17α-estradiol, is considered less carcinogenic, and non-feminising in males, however little...
The current study aims to analyze the withdrawal effects (i.e. psychological and physiological) of methamphetamine on addicts in Khyber Pakhtunkhwa province Pakistan. A sample 180 users was interviewed through an interview schedule by snowball sampling technique. For testing association between independent variable withdrawal) dependent variables physiological effects) a Chi-square test adminis...
CONTEXT Methamphetamine is associated with psychotic phenomena, but it is not clear to what extent this relationship is due to premorbid psychosis among people who use the drug. OBJECTIVE To determine the change in the probability of psychotic symptoms occurring during periods of methamphetamine use. DESIGN Longitudinal prospective cohort study. A fixed-effects analysis of longitudinal pane...
The clinical presentation, course and treatment of methamphetamine (METH)-associated psychosis (MAP) are similar to that observed in schizophrenia (SCZ) and subsequently MAP has been hypothesized as a pharmacological and environmental model of SCZ. However, several challenges currently exist in diagnosing MAP accurately at the molecular and neurocognitive level before the MAP model can contribu...
BACKGROUND Prolonged exposure to methamphetamine (meth) has neurotoxic effects and impairs neurocognitive functions. This study aims to ascertain whether meth users who experience persistent psychosis suffer more severe cognitive impairment than those not experiencing persistent psychosis. METHODS This cross-sectional study includes 252 participants: 25 meth users without psychosis (METH-P), ...
Methamphetamine (Meth) is a widely abused stimulant drug, but this abuse is associated with an increased risk of developing psychosis. In addition to its well-known action on brain dopamine, Meth also affects serotonergic (5-HT) neurons. The aim of this study was to investigate this role in mice, which lack one of the main serotonin receptors, the 5-HT1A receptor, which has been implicated in b...
The aim of the present study was to gain a better understanding role brain-derived neurotrophic factor (BDNF) and dopamine D3 receptors in effects chronic methamphetamine (METH) on prepulse inhibition (PPI), an endophenotype psychosis. We compared effect three-week adolescent METH treatment protocol regulation PPI wildtype mice, BDNF heterozygous mice (HET), receptor knockout (D3KO), double-mut...
The neuronal nitric oxide synthase gene (NOS1) is located at 12q24, a susceptibility region for schizophrenia, and produces nitric oxide (NO). NO has been reported to play important roles as a gaseous neurotransmitter in brain. NO is a second messenger for the N-methyl-D aspartate (NMDA) receptor and is related to the dopaminergic system. Because the symptomatology of methamphetamine (METH) use...
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