OBJECTIVE Impaired insulin-mediated hepatic glucose uptake (HGU) has been implicated in the hyperglycemia of type 2 diabetes. We examined the effects of metformin (2 g/day) and rosiglitazone (8 mg/day) monotherapy on HGU and its relation to subcutaneous fat, visceral fat (VF), and whole-body insulin-mediated glucose metabolism in type 2 diabetic patients. RESEARCH DESIGN AND METHODS Glucose u...

Background and Purpose: Insulin-like growth factor-1 (IGF-1) was found to have a role in both glucose homeostasis and cardiovascular disease. The present study was designed to compare the effects of fluvastatin and metformin on IGF-1 mRNA expression within the liver and on other individual components of the metabolic syndrome induced in rats by high fructose feeding. Experimental Approach: Rats...

BACKGROUND Metformin, an oral biguanide traditionally used for the treatment of type 2 diabetes, is widely used for the management of polycystic ovary syndrome (PCOS)-related anovulation. Because of the significant prevalence of insulin resistance and glucose intolerance in PCOS patients, and their putative role in ovulatory dysfunction, the use of metformin was touted as a means to improve ovu...

OBJECTIVES The prevalence of type 2 diabetes in American adolescents has increased markedly during the past generation. Although the factors that contribute to the development of type 2 diabetes are complex and not wholly elucidated, the triad of severe obesity, hyperinsulinemia, and a family history of type 2 diabetes places a child at an increased risk for development of the disease. Current ...

There has been substantial interest in investigating whether the long-term administration of metformin to diabetic patients leads to a reduction in the incidence of malignancies in general or more specifically colorectal cancer. A number of studies have been published on this field with mixed results (1,2). In this issue of Diabetes Care, Zhang et al. (3) report the results of a meta-analysis o...

Epidemiological studies suggest a positive association between obesity and type 2 diabetes mellitus (T2D) with the risk of cancer and cancer-related mortality. Insulin resistance, hyperinsulinemia, increased levels of IGF, elevated levels of steroid and peptide hormones, and inflammatory markers appear to play a role in the connection between these different diseases. Medications, such as metfo...

Background. The impact of insulin resistance on the probability increase in thyroid cancer risk has been drawing a lot attention researchers lately. This problem is far from being completely solved. Studying this interrelationship may influence effectiveness treatment mentioned widespread pathology.
 Purpose – to review present literature sources research between and cancer, also possible ...

The purpose of this study is to investigate the utility insulin curve with Oral Glucose Tolerance Test (OGTT) in identifying hyperinsulinemia Polycystic Ovarian Syndrome (PCOS) patients. Further, identify clinical characteristics PCOS subpopulation that has a normal OGTT, but presence by curve, compared patients without evidence hyperinsulinemia. A retrospective cross-sectional was performed on...

Topic: Mutual association and connection study between the obesity, visceral obesity, insulin desensitation (with the conesquential hyperinsulinemia), type 2 diabetes, dyslipoproteinemia and anthropometric characteristics of the patients with the metabolic syndrom are the subject of many epidemiological studies. However, it is noticed that there are certain disagreements and contradictions in d...