metformin hydrochloride (mfh) is an oral anti-diabetic drug of biguanide class. two selective spectrophotometric methods were presented for the determination of mfh in pharmaceuticals. the methods were based on the measurement of yellow-coloured charge-transfer complexes formed between mfh and two poly-nitrophenols, namely, 2,4-dinitrophenol (dnp method, at 405 nm) and picric acid (pa method; a...

Natural materials are preferred over synthetic counterparts because of their biodegradable and biocompatible nature. The present work was proposed to utilize mucilage from natural source for the development of controlled release formulation of metformin hydrochloride. Natural mucilaginous substance extracted from Dillenia indica L. (DI) fruit was used in fabricating controlled release microsphe...

The present work envisages utilisation of biodegradable and biocompatible material from natural sources for the development of controlled release microspheres of metformin hydrochloride (MetH). Natural polysaccharides extracted from Dillenia indica L. (DI), Abelmoschus esculentus L. (AE) and Bora rice flour were used in fabricating controlled release microspheres. The microspheres were prepared...

A new simple, fast accurate and reproducible reverse phase high performance liquid chromatographic method has been developed and validated for simultaneous estimation of Metformin Hydrochloride and Glimepiride from tablet dosage form. The method was developed using Waters HPLC system on C18 column (Spherisorb ODS 2: 250mm x 4.6 μm) using a mixture of 25mM Phosphoric Acid pH 3.0 (with KOH) and A...

A novel, sensitive, stability indicating RP-HPLC method has been developed for the quantitative estimation of Metformin Hydrochloride impurities in both bulk drugs and pharmaceutical dosage forms. Effective chromatographic separation was achieved on a C8 stationary phase with simple mobile phase combination delivered in a isocratic mode and quantitation was by ultraviolet detection at 218 nm. T...

A simple, economic, sensitive, precise and accurate UV spectrophotometric method was developed and validated for quantification of Metformin hydrochloride in bulk and in tablet dosage form. Adequate drug solubility and maximum assay sensitivity was found in 0.01N sodium hydroxide at 233nm. Calibration graph constructed at 233nm was linear in concentration range of 1-25μg/ml with correlation coe...

The study was aimed at developing extended release matrix tablets of poorly water-soluble diclofenac sodium and highly water-soluble metformin hydrochloride by direct compression using cashew gum, xanthan gum and hydroxypropylmethylcellulose (HPMC) as release retardants. The suitability of light grade cashew gum as a direct compression excipient was studied using the SeDeM Diagram Expert System...

In this study, as an approach to possible pharmacokinetic interactions between antidiabetic agents and health foods, we investigated the binding of metformin and glibenclamide to aojiru, kurosu, and blueberry extract using a dialysis method. The permeation of metformin from the inner to the outer side of the dialysis tube during 90 min was not altered in the presence of aojiru or kurosu, and sl...

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