نتایج جستجو برای: metabolic profiling

تعداد نتایج: 296594  

2013
Marc-Emmanuel Dumas Laetitia Davidovic

The development of high-throughput metabolic profiling and the study of the metabolome are particularly important in brain research where small molecules or metabolites play fundamental signalling roles: neurotransmitters, signalling lipids, osmolytes and even ions. Metabolic profiling has shown that metabolic perturbations in the brain go beyond alterations of neurotransmission and that variat...

Journal: :PLoS ONE 2009
Suzan Wopereis Carina M. Rubingh Marjan J. van Erk Elwin R. Verheij Trinette van Vliet Nicole H. P. Cnubben Age K. Smilde Jan van der Greef Ben van Ommen Henk F. J. Hendriks

BACKGROUND The prevalence of overweight is increasing globally and has become a serious health problem. Low-grade chronic inflammation in overweight subjects is thought to play an important role in disease development. Novel tools to understand these processes are needed. Metabolic profiling is one such tool that can provide novel insights into the impact of treatments on metabolism. METHODOL...

2015
Goncalo D. S. Correia Keng Wooi Ng Anisha Wijeyesekera Sandra Gala-Peralta Rachel Williams S. MacCarthy-Morrogh Beatriz Jiménez David Inwald Duncan Macrae Gary Frost Elaine Holmes Nazima Pathan

OBJECTIVE Inflammation and metabolism are closely interlinked. Both undergo significant dysregulation following surgery for congenital heart disease, contributing to organ failure and morbidity. In this study, we combined cytokine and metabolic profiling to examine the effect of postoperative tight glycemic control compared with conventional blood glucose management on metabolic and inflammator...

Journal: :The Plant cell 2001
U Roessner A Luedemann D Brust O Fiehn T Linke L Willmitzer A Fernie

Metabolic profiling using gas chromatography-mass spectrometry technologies is a technique whose potential in the field of functional genomics is largely untapped. To demonstrate the general usefulness of this technique, we applied to diverse plant genotypes a recently developed profiling protocol that allows detection of a wide range of hydrophilic metabolites within a single chromatographic r...

Journal: :Molecules 2014
Pui Hei Chan Wendy L Zhang Chung-Ho Lau Chi Yuen Cheung Hector C Keun Karl W K Tsim Henry Lam

Angelica Radix, the roots of the genus Angelica, has been used for more than 2,000 years as a traditional medicine in Eastern Asia. The Chinese Pharmacopoeia records more than 100 herbal formulae containing Angelica roots. There are two common sources of Angelica roots, Angelica sinensis from China and A. gigas from Korea. The two species of Angelica roots differ in their chemical compositions,...

2018
Nusrat S Shommu Craig N Jenne Jaime Blackwood Ari R Joffe Dori-Ann Martin Graham C Thompson Hans J Vogel

Various limitations hinder the timely and accurate diagnosis of appendicitis in pediatric patients. The present study aims to investigate the potential of metabolomics and cytokine profiling for improving the diagnosis of pediatric appendicitis. Serum and plasma samples were collected from pediatric patients for metabolic and inflammatory mediator analyses respectively. Targeted metabolic profi...

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