نتایج جستجو برای: metabolic detoxification
تعداد نتایج: 224739 فیلتر نتایج به سال:
BACKGROUND The capacity of Aedes mosquitoes to resist chemical insecticides threatens the control of major arbovirus diseases worldwide. Until alternative control tools are widely deployed, monitoring insecticide resistance levels and identifying resistance mechanisms in field mosquito populations is crucial for implementing appropriate management strategies. Metabolic resistance to pyrethroids...
Phenanthrene is the simplest polycyclic aromatic hydrocarbon (PAH) containing a bay region, a feature closely associated with carcinogenicity. We have proposed that measurement of phenanthrene metabolites in human urine could be used to identify interindividual differences in metabolic activation and detoxification of PAH, and that these differences may be related to cancer susceptibility in sm...
“Il Principe” (the Prince) is the nickname given to a spectacular Mid Upper Palaeolithic (Gravettian) burial discovered at Arene Candide, Italy in 1942. Arene Candide is a large cave located about 90 m above sea level on the slope of the Caprazoppa promontory, along the Ligurian coast near Finale Ligure (Savona, Italy). The cave is named after a dune of white siliceous sand of aeolian origin, b...
The levels of resistance to two organophosphate acaricides, coumaphos and diazinon, in several Mexican strains of Boophilus microplus (Canestrini) were evaluated using the FAO larval packet test. Regression analysis of LC50 data revealed a significant cross-resistance pattern between those two acaricides. Metabolic mechanisms of resistance were investigated with synergist bioassays. Piperonyl b...
Iron (Fe) is an essential micronutrient for plants, as a cofactor in multi-heme cytochromes and within iron-sulfur clusters. However, Fe can be toxic at high concentrations. Free cells disrupt the cell redox balance toward pro-oxidant state, generating oxidative stress. The focuses of this review were to elucidate detoxification strategies used by well describe excess effects on plant body its ...
BACKGROUND Triatomine insects are vectors of Trypanosoma cruzi, a protozoan parasite that is the causative agent of Chagas' disease. This is a neglected disease affecting approximately 8 million people in Latin America. The existence of diverse pyrethroid resistant populations of at least two species demonstrates the potential of triatomines to develop high levels of insecticide resistance. The...
Adenosine deaminase (ADA) deficiency is caused by a purine metabolic dysfunction, leading to severe combined immunodeficiency (SCID) and multiple organ damage. To investigate the efficacy of ex vivo gene therapy with self-inactivating lentiviral vectors (LVs) in correcting this complex phenotype, we used an ADA(-/-) mouse model characterized by early postnatal lethality. LV-mediated ADA gene tr...
The circadian clock is an endogenous biological timekeeping system that synchronizes physiology and behavior to day/night cycles. A wide variety of processes throughout the entire gastrointestinal tract and notably the liver appear to be under circadian control. These include various metabolic functions such as nutrient uptake, processing, and detoxification, which align organ function to cycle...
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