نتایج جستجو برای: mesothelioma

تعداد نتایج: 8141  

2009
Fang-Yi Lee Mei-Chin Wen John Wang Chun-Kai Tseng

Malignant mesothelioma is an uncommon tumor of serosal surfaces. The most common sites of origin include the pleura and the peritoneum. Malignant mesothelioma of the tunica vaginalis testis is rare. We describe a 78 year-old man with a 2-month history of a rapidly enlarging scrotum. The initial pathologic diagnosis was fibrous pseudotumor by the presence of cellular spindle cells and the backgr...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2016
Andrea Napolitano Daniel J Antoine Laura Pellegrini Francine Baumann Ian Pagano Sandra Pastorino Chandra M Goparaju Kirill Prokrym Claudia Canino Harvey I Pass Michele Carbone Haining Yang

PURPOSE To determine whether serum levels of high mobility group box protein 1 (HMGB1) could differentiate malignant mesothelioma patients, asbestos-exposed individuals, and unexposed controls. EXPERIMENTAL DESIGN Hyperacetylated and nonacetylated HMGB1 (together referred to as total HMGB1) were blindly measured in blood collected from malignant mesothelioma patients (n = 22), individuals wit...

2014
Filip Mundt Henrik J. Johansson Jenny Forshed Sertaç Arslan Muzaffer Metintas Katalin Dobra Janne Lehtiö Anders Hjerpe

Malignant mesothelioma is an aggressive asbestos-induced cancer, and affected patients have a median survival of approximately one year after diagnosis. It is often difficult to reach a conclusive diagnosis, and ancillary measurements of soluble biomarkers could increase diagnostic accuracy. Unfortunately, few soluble mesothelioma biomarkers are suitable for clinical application. Here we screen...

Journal: :The New England journal of medicine 2012
Harvey I Pass Stephen M Levin Michael R Harbut Jonathan Melamed Luis Chiriboga Jessica Donington Margaret Huflejt Michele Carbone David Chia Lee Goodglick Gary E Goodman Mark D Thornquist Geoffrey Liu Marc de Perrot Ming-Sound Tsao Chandra Goparaju

BACKGROUND New biomarkers are needed to detect pleural mesothelioma at an earlier stage and to individualize treatment strategies. We investigated whether fibulin-3 in plasma and pleural effusions could meet sensitivity and specificity criteria for a robust biomarker. METHODS We measured fibulin-3 levels in plasma (from 92 patients with mesothelioma, 136 asbestos-exposed persons without cance...

2018
Alenka Franko Nika Kotnik Katja Goricar Viljem Kovac Metoda Dodic-Fikfak Vita Dolzan

Background Malignant mesothelioma is a rare cancer with poor outcome, associated with asbestos exposure. Reactive oxygen species may play an important role in the mechanism of carcinogenesis; therefore, genetic variability in antioxidative defence may modify an individual's susceptibility to this cancer. This study investigated the influence of functional polymorphisms of NQO1, CAT, SOD2 and hO...

Journal: :Molecular cancer therapeutics 2015
Snehal Dabir Adam Kresak Michael Yang Pingfu Fu Gary Wildey Afshin Dowlati

CD30 is a cytokine receptor belonging to the TNF superfamily (TNFRSF8) that acts as a regulator of apoptosis. The presence of CD30 antigen is important in the diagnosis of Hodgkin disease and anaplastic large cell lymphoma. There have been sporadic reports of CD30 expression in nonlymphoid tumors, including malignant mesothelioma. Given the remarkable success of brentuximab vedotin, an antibody...

MOHAMMAD REZA MOTAMEDI, P SHISHINEH,

Primary malignant neoplasms of the pericardium are rare and are predominantly mesotheliomas, followed by benign localized fibrous mesothelioma, malignant fibrosarcoma, angiosarcoma and benign and malignant teratomas. 1 This article concerns an atypical presentation of this malignant tumor with symptoms and signs of pericardial effusion. This unusual feature was complete encasement of the h...

2011
Ming-Szu Hung Jian-Hua Mao Zhidong Xu Cheng-Ta Yang Jau-Song Yu Chansonette Harvard Yu-Ching Lin Dawn Therese Bravo David M Jablons Liang You

Cullin 4A (Cul4A) is important in cell survival, development, growth and the cell cycle, but its role in mesothelioma has not been studied. For the first time, we identified amplification of the Cul4A gene in four of five mesothelioma cell lines. Consistent with increased Cul4A gene copy number, we found that Cul4A protein was overexpressed in mesothelioma cells as well. Cul4A protein was also ...

Journal: :Thorax 2002
A Baldi A M Groeger V Esposito R Cassandro G Tonini T Battista M P Di Marino B Vincenzi M Santini A Angelini R Rossiello F Baldi M G Paggi

BACKGROUND Mesothelioma is the most commonly occurring primary pleural neoplasm. Several studies have documented an increase in the incidence of this malignancy during the last decades. Although the association between asbestos exposure and development of mesothelioma is generally accepted, the exact mechanism of carcinogenesis is unknown. Recently, Simian virus 40 large T antigen (SV40 Tag) ex...

2018
Joyce K. Thompson Anurag Shukla Alan L. Leggett Phillip B. Munson Jill M. Miller Maximilian B. MacPherson Stacie L. Beuschel Harvey I. Pass Arti Shukla

Malignant mesothelioma is an aggressive cancer in desperate need of treatment. We have previously shown that extracellular signaling regulated kinase 5 (ERK5) plays an important role in mesothelioma pathogenesis using ERK5 silenced human mesothelioma cells exhibiting significantly reduced tumor growth in immunocompromised mice. Here, we used a specific ERK 5 inhibitor, XMD8-92 in various in vit...

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