نتایج جستجو برای: mesenchymal stromal cell

تعداد نتایج: 1733547  

2013
Francesca Rossi Maria Ester Bernardo Giulia Bellini Livio Luongo Antonella Conforti Iolanda Manzo Francesca Guida Luigia Cristino Roberta Imperatore Stefania Petrosino Bruno Nobili Vincenzo Di Marzo Franco Locatelli Sabatino Maione

Mesenchymal stromal cells are non-hematopoietic, multipotent progenitor cells producing cytokines, chemokines, and extracellular matrix proteins that support hematopoietic stem cell survival and engraftment, influence immune effector cell development, maturation, and function, and inhibit alloreactive T-cell responses. The immunosuppressive properties of human mesenchymal stromal cells have att...

2017
Cristina Trento Ilaria Marigo Alice Pievani Antonio Galleu Luigi Dolcetti Chun-Yin Wang Marta Serafini Vincenzo Bronte Francesco Dazzi

Bone marrow microenvironment is fundamental for hematopoietic homeostasis. Numerous efforts have been made to reproduce or manipulate its activity to facilitate engraftment after hematopoietic stem cell transplantation but clinical results remain unconvincing. This probably reflects the complexity of the hematopoietic niche. Recent data have demonstrated the fundamental role of stromal and myel...

Journal: :trauma monthly 0
kamal seyed foroutan department of plastic surgery, hazrat fatemeh hospital, iran university of medical sciences, tehran, ir iran; department of plastic surgery, hazrat fatemeh hospital, iran university of medical sciences, tehran, ir iran. tel: +98-2188890889 ali khodarahmi department of plastic surgery, bahonar hospital, kerman university of medical sciences, kerman, ir iran hootan alavi department of plastic surgery, hazrat fatemeh hospital, iran university of medical sciences, tehran, ir iran sepehr pedram veterinary faculty, hazrat fatemeh hospital, iran university of medical sciences, tehran, ir iran mohamad reza baghaban eslaminejad department of stem cells and developmental biology, cell science research center, royan institute for stem cell biology and technology, acecr, tehran, ir iran sima bordbar department of stem cells and developmental biology, cell science research center, royan institute for stem cell biology and technology, acecr, tehran, ir iran

conclusions the results of this study showed that the meticulous microsurgical nerve repair, which was performed using the vein tubulization induced significantly better sciatic nerve regeneration. however, the addition of bone marrow mesenchymal stem cell to vein conduit failed to promote any significant changes in regeneration outcome. results all animals tolerated the surgical procedures and...

Journal: :iranian red crescent medical journal 0
iman ahrari student research committee, shiraz university of medical sciences (sums), shiraz, ir iran nima purhabibi zarandi student research committee, shiraz university of medical sciences (sums), shiraz, ir iran mohsen khosravi maharlooei student research committee, shiraz university of medical sciences (sums), shiraz, ir iran ahmad monabati department of pathology, shiraz university of medical sciences (sums), shiraz, ir iran armin attar department of cardiovascular medicine, shiraz university of medical sciences (sums), shiraz, ir iran; department of cardiovascular medicine, shiraz university of medical sciences (sums), shiraz, ir iran. tel: +98-9177141797, fax: +98-7112349521 sajjad ahrari student research committee, shiraz university of medical sciences (sums), shiraz, ir iran

conclusions according to the results of the present study, it can be concluded that adipose derived mscs can be cultured in serum-free media with no change in their differentiating capacity. this finding gives us a hope for future cell therapy studies and trials with little concern about zoonotic infections or immunological reaction. results the isolated cells showed adherent spindle shaped mor...

Journal: :Experimental hematology 2002
Pierre Charbord Robert Oostendorp Wenxin Pang Olivier Hérault Frederic Noel Takashi Tsuji Elaine Dzierzak Bruno Péault

OBJECTIVE To better understand the differentiation of stromal cells of the hematopoietic microenvironment, we set out to characterize stromal cells from the different developmental sites of hematopoiesis in the mouse (30 bone marrow, 7 spleen, 3 embryonic and 15 fetal liver, 6 yolk sac, and 6 aorta-gonad-mesonephros lines) for expression of 22 cytoskeletal, membrane, and extracellular matrix pr...

2018
Sharad K. Mittal Alireza Mashaghi Afsaneh Amouzegar Mingshun Li William Foulsham Srikant K. Sahu Sunil K. Chauhan

Purpose Neutrophil-secreted effector molecules are one of the primary causes of tissue damage during corneal inflammation. In the present study, we have investigated the effect of stromal cells in regulating neutrophil expression of tissue-damaging enzymes, myeloperoxidase (MPO), and N-elastase (ELANE). Methods Bone marrow-purified nonhematopoietic mesenchymal stromal cells and formyl-methion...

Journal: :All life 2022

Mesenchymal stem cells (MSCs) show high expression of PD-L1. Exosomes can transmit signals between tumor and stromal cells; however, the effect tumor-derived exosomes on cell signaling pathways is unclear. The PD-L1 in bone marrow mesenchymal (BMMSCs) was detected by western blot RT-PCR. effects gastric cancer line-derived BMMSC migration conditioned medium from educated BMMSCs were analyzed. O...

Journal: :Journal of cell science 2000
A Muraglia R Cancedda R Quarto

Bone marrow stromal cells can give rise to several mesenchymal lineages. The existence of a common stem/progenitor cell, the mesenchymal stem cell, has been proposed, but which developmental stages follow this mesenchymal multipotent progenitor is not known. Based on experimental evidence, a model of mesenchymal stem cell differentiation has been proposed in which individual lineages branch dir...

Journal: :Haematologica 2012
Carlos Santamaría Sandra Muntión Beatriz Rosón Belén Blanco Olga López-Villar Soraya Carrancio Fermín M Sánchez-Guijo María Díez-Campelo Stela Alvarez-Fernández María E Sarasquete Javier de las Rivas Marcos González Jesús F San Miguel María Consuelo Del Cañizo

UNLABELLED Background Recent findings suggest that a specific deletion of Dicer1 in mesenchymal stromal cell-derived osteoprogenitors triggers several features of myelodysplastic syndrome in a murine model. Our aim was to analyze DICER1 and DROSHA gene and protein expression in mesenchymal stromal cells (the osteoblastic progenitors) obtained from bone marrow of myelodysplastic syndrome patient...

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